Results 11 to 20 of about 5,909 (195)

SPAK and OSR1 Sensitive Kir2.1 K+ Channels

Neurosignals, 2015
Background/Aims: Kir2.1 (KCNJ2) channels are expressed in neurons, skeletal muscle and cardiac tissue and maintain the resting membrane potential. The activity of those channels is regulated by diverse signalling molecules.
Myriam Fezai, Musaab Ahmed, Zohreh Hosseinzadeh, Bernat Elvira, Florian Lang   +4 more
doaj   +3 more sources

Cdo Regulates Surface Expression of Kir2.1 K+ Channel in Myoblast Differentiation. [PDF]

PLoS ONE, 2016
A potassium channel Kir2.1-associated membrane hyperpolarization is required for myogenic differentiation. However the molecular regulatory mechanisms modulating Kir2.1 channel activities in early stage of myogenesis are largely unknown.
Young-Eun Leem, Hyeon-Ju Jeong, Hyun-Ji Kim, Jewoo Koh, KyeongJin Kang, Gyu-Un Bae, Hana Cho, Jong-Sun Kang   +7 more
doaj   +5 more sources

Ion-ing out the genetic variants of Kir2.1

eLife, 2022
Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases.
Braden S Fallon, Justin G English
doaj   +3 more sources

Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1

JCI Insight, 2022
In the resistance artery endothelium, we show phosphatidylserine (PS) localizes to a specific subpopulation of myoendothelial junctions (MEJs), signaling microdomains that regulate vasodilation. In silico data has implied PS may compete with PIP2 binding
Claire A. Ruddiman, R. Peckham, Melissa A. Luse, Y. Chen, M. Kuppusamy, Bruce A. Corliss, J. Hall, Chien-Jung Lin, S. Peirce, Swapnil K. Sonkusare, R. Mecham, J. Wagenseil, B. Isakson   +12 more
semanticscholar   +5 more sources

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization [PDF]

Frontiers in Immunology
IntroductionChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains a challenging urological condition. This study investigated the therapeutic potential of transcutaneous electrical nerve stimulation (TENS) in experimental autoimmune ...
Ting Hong, Ting Hong, Xinyu Liu, Xinyu Liu, Zepai Chi, Guoyuan Liu, Yuanfeng Zhang, Xuanhao Lin, Peixiu Yao, Qingyun Gong, Yonghai Zhang, Yonghai Zhang, Xuwei Hong, Xuwei Hong   +13 more
doaj   +2 more sources

In silico models of the macromolecular NaV1.5-KIR2.1 complex

Frontiers in Physiology
In cardiac cells, the expression of the cardiac voltage-gated Na+ channel (NaV1.5) is reciprocally regulated with the inward rectifying K+ channel (KIR2.1).
Anna Stary-Weinzinger
doaj   +2 more sources

Endocannabinoid regulation of inward rectifier potassium (Kir) channels [PDF]

Frontiers in Pharmacology
The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The functions of Kir2.1 channels are dependent on their lipid environment, including the availability
Sultan Mayar, Mariia Borbuliak, Andreas Zoumpoulakis, Tahar Bouceba, Madeleine M. Labonté, Ameneh Ahrari, Niveny Sinniah, Mina Memarpoor-Yazdi, Catherine Vénien-Bryan, D. Peter Tieleman, Nazzareno D’Avanzo   +10 more
doaj   +2 more sources

Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels

Acta Pharmaceutica, 2021
Terfenadine is a second-generation H1-antihistamine that despite potentially can produce severe side effects it has recently gained attention due to its anticancer properties. Lately, the subfamily 2 of inward rectifier potassium channels (Kir2) has been
Delgado-Ramírez Mayra, Rodriguez-Leal Fanny Junue, Rodríguez-Menchaca Aldo Azmar, Moreno-Galindo Eloy Gerardo, Sanchez-Chapula José Antonio, Ferrer Tania   +5 more
doaj   +3 more sources

Impairment of microvascular endothelial Kir2.1 channels contributes to endothelial dysfunction in human hypertension.

Am J Physiol Heart Circ Physiol
Hypertension is associated with decreased endothelial function through reduced contributions of NO. We previously discovered that flow-induced NO production in resistance arteries of mice and humans critically depends on endothelial inwardly-rectifying K+
Do Couto NF, Fancher I, Granados ST, Cavalcante-Silva J, Beverley KM, Ahn SJ, Hwang CL, Phillips SA, Levitan I.   +8 more
europepmc   +2 more sources

Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone [PDF]

Frontiers in Physiology, 2017
Cardiac Kir2.1 and Nav1.5 channels generate the inward rectifier K+ (IK1) and the Na+ (INa) currents, respectively. There is a mutual interplay between the ventricular INa and IK1 densities, because Nav1.5 and Kir2.1 channels exhibit positive reciprocal modulation.
Utrilla, Raquel G, Nieto-Marín, Paloma, Alfayate, Silvia, Tinaquero, David, Matamoros, Marcos, Pérez-Hernández, Marta, Sacristán, Sandra, Ondo, Lorena, de Andrés, Raquel, Díez-Guerra, F Javier, Tamargo, Juan, Delpón, Eva, Caballero, Ricardo   +12 more
openaire   +5 more sources