Results 21 to 30 of about 5,909 (195)

Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents [PDF]

Molecular & Cellular Proteomics, 2020
Kir2.1, a strong inward rectifier potassium channel encoded by the KCNJ2 gene, is a key regulator of the resting membrane potential of the cardiomyocyte and plays an important role in controlling ventricular excitation and action potential duration in the human heart. Mutations in KCNJ2 result in inheritable cardiac diseases in humans, e.g.
Sung-Soo Park, Daniela Ponce-Balbuena, Rork Kuick, Guadalupe Guerrero-Serna, Justin Yoon, Dattatreya Mellacheruvu, Kevin P. Conlon, Venkatesha Basrur, Alexey I. Nesvizhskii, José Jalife, Jean-François Rual   +10 more
openaire   +3 more sources

Channelopathies: Kir2.1 mutations jeopardize many cell functions [PDF]

Current Biology, 2001
Andersen's syndrome is caused by mutations in the potassium channel Kir2.1, a major determinant of resting membrane potential. The clinical features of this disease illustrate the importance of a stable resting membrane potential for many cell functions.
Jongsma, H. J., Wilders, R.
openaire   +3 more sources

Functional consequences of Kir2.1/Kir2.2 subunit heteromerization [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
Kir2 subunits form channels that underlie classical strongly inwardly rectifying potassium currents. While homomeric Kir2 channels display a number of distinct and physiologically important properties, the functional properties of heteromeric Kir2 assemblies, as well as the stoichiometries and the arrangements of Kir2 subunits in native channels ...
Panama, Brian K., McLerie, Meredith, Lopatin, Anatoli N.   +2 more
openaire   +2 more sources

Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

Frontiers in Pharmacology, 2020
Andersen–Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential.
Reem Handklo-Jamal, Eshcar Meisel, Eshcar Meisel, Daniel Yakubovich, Daniel Yakubovich, Leonid Vysochek, Roy Beinart, Roy Beinart, Michael Glikson, Michael Glikson, Julie R. McMullen, Nathan Dascal, Eyal Nof, Eyal Nof, Shimrit Oz, Shimrit Oz   +15 more
doaj   +1 more source

NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim The aim of this study is to determine the possible role of N‐methyl‐D‐aspartate receptor (NMDAR) dysregulation in the ischemic electrical remodeling observed in patients with myocardial infarction (MI) and elucidate the underlying mechanisms.
He Y, Zhang H, Zhang Q, Sun Z, Sun X, Xia L, Zheng L, Wang L.   +7 more
europepmc   +2 more sources

Hypercholesterolemia‐Induced Loss of Flow‐Induced Vasodilation and Lesion Formation in Apolipoprotein E–Deficient Mice Critically Depend on Inwardly Rectifying K+ Channels

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundHypercholesterolemia‐induced decreased availability of nitric oxide (NO) is a major factor in cardiovascular disease. We previously established that cholesterol suppresses endothelial inwardly rectifying K+ (Kir) channels and that Kir2.1 is an ...
Ibra S. Fancher, Sang Joon Ahn, Crystal Adamos, Catherine Osborn, Myung‐Jin Oh, Yun Fang, Catherine A. Reardon, Godfrey S. Getz, Shane A. Phillips, Irena Levitan   +9 more
doaj   +1 more source

Linkage analysis reveals allosteric coupling in Kir2.1 channels [PDF]

Journal of General Physiology, 2018
Potassium-selective inward rectifier (Kir) channels are a class of membrane proteins necessary for maintaining stable resting membrane potentials, controlling excitability, and shaping the final repolarization of action potentials in excitable cells. In addition to the strong inward rectification of the ionic current caused by intracellular blockers ...
Daniel M. Sigg, Hsueh-Kai Chang, Ru-Chi Shieh   +2 more
openaire   +2 more sources

Up-Regulation of Kir2.1 (KCNJ2) by the Serum & Glucocorticoid Inducible SGK3

Cellular Physiology and Biochemistry, 2014
Background/Aims: The serum & glucocorticoid inducible kinase SGK3, an ubiquitously expressed serine/threonine kinase, regulates a variety of ion channels.
Carlos Munoz, Tatsiana Pakladok, Ahmad Almilaji, Bernat Elvira, Niels Decher, Ekaterina Shumilina, Florian Lang   +6 more
doaj   +1 more source

Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1

JCI Insight, 2023
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain ...
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson   +12 more
doaj   +1 more source

PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Years before the emergence of infarctions or significant cognitive decline, patients with cerebral small vessel disease (SVD) show a deterioration in the ability of the brain to augment blood flow locally in response to increases in neuronal
Fabrice Dabertrand, O. Harraz, M. Koide, T. Longden, Amanda C Rosehart, David Hill-Eubanks, A. Joutel, M. Nelson   +7 more
semanticscholar   +1 more source