Results 31 to 40 of about 5,909 (195)
Shear stress regulates the endothelial Kir2.1 ion channel [PDF]
Proceedings of the National Academy of Sciences, 2002 Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K + conductance, which suggests that ion channels are involved in
Jeff H, Hoger +3 more
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Inhibition of electrical activity by retroviral infection with Kir2.1 transgenes disrupts electrical differentiation of motoneurons. [PDF]
PLoS ONE, 2008 Network-driven spontaneous electrical activity in the chicken spinal cord regulates a variety of developmental processes including neuronal differentiation and formation of neuromuscular structures.
Yone Jung Yoon +3 more
doaj +1 more source
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia
Biofactors, 2023 Melatonin is a pleiotropic biofactor and an effective antioxidant and free radical scavenger and, as such, can be protective in oxidative stress‐related brain conditions including epilepsy and aging.
Alessia Remigante +7 more
semanticscholar +1 more source
Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification
Frontiers in Physiology, 2019 KIR2.1 potassium channels, producing inward rectifier potassium current (IK1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes.
Muge Qile +6 more
doaj +1 more source
Chronic Propafenone Application Increases Functional KIR2.1 Expression In Vitro
Pharmaceuticals, 2023 Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but ...
E. Li +3 more
semanticscholar +1 more source
Regulation of Kir2.1 channels by the Rho‐GTPase, Rac1 [PDF]
Journal of Cellular Physiology, 2008 AbstractMutations in Kir2.1 inwardly rectifying potassium channels are associated with Andersen syndrome, a disease characterized by potentially fatal cardiac arrhythmias. While several Andersen‐associated mutations affect membrane expression, the cytoplasmic signals that regulate Kir2.1 trafficking are poorly understood.
Stephanie B, Boyer +2 more
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Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes [PDF]
American Journal of Physiology-Heart and Circulatory Physiology, 2020 We identify cell culture density and cell-cell contact as an important factor in determining the expression of a key ion channel at the transcriptional and the protein levels, KCNJ2/Kir2.1, and its contribution to the electrophysiology of human induced pluripotent stem cell-derived cardiomyocytes.
Weizhen Li +2 more
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Cholesterol Sensitivity and Lipid Raft Targeting of Kir2.1 Channels [PDF]
Biophysical Journal, 2004 This study investigates how changes in the level of cellular cholesterol affect inwardly rectifying K+ channels belonging to a family of strong rectifiers (Kir2). In an earlier study we showed that an increase in cellular cholesterol suppresses endogenous K+ current in vascular endothelial cells, presumably due to effects on underlying Kir2.1 channels.
Romanenko, Victor G. +6 more
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bioRxiv, 2023 Macrophages and satellite glial cells are found between injured and uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored the mechanism of neuro-immune and neuron–glia crosstalk leading to hyperexcitability of DRG neurons.
E. A. Konnova +5 more
semanticscholar +1 more source
Genetically engineered excitable cardiac myofibroblasts coupled to cardiomyocytes rescue normal propagation and reduce arrhythmia complexity in heterocellular monolayers. [PDF]
PLoS ONE, 2013 The use of genetic engineering of unexcitable cells to enable expression of gap junctions and inward rectifier potassium channels has suggested that cell therapies aimed at establishing electrical coupling of unexcitable donor cells to host ...
Luqia Hou, Bin Hu, José Jalife
doaj +1 more source