Results 41 to 50 of about 5,909 (195)

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

Science Advances, 2022
We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key role in maintaining resting membrane ...
C. Fernandes, Dania Zuniga, Charline Fagnen, V. Kugler, R. Scala, G. Péhau-Arnaudet, R. Wagner, D. Pérahia, S. Bendahhou, C. Vénien-Bryan   +9 more
semanticscholar   +1 more source

Styrax blocks inward and outward current of Kir2.1 channel [PDF]

Channels, 2016
Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1.
Shuxi, Ren, Chunli, Pang, Junwei, Li, Yayue, Huang, Suhua, Zhang, Yong, Zhan, Hailong, An   +6 more
openaire   +2 more sources

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Journal of Biomedical Science, 2017
Background The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential.
Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A. G. van der Heyden   +10 more
doaj   +1 more source

Altering integrin engagement regulates membrane localization of Kir2.1 channels [PDF]

Journal of Cell Science, 2019
ABSTRACT How ion channels localize and distribute on the cell membrane remains incompletely understood. We show that interventions that vary cell adhesion proteins and cell size also affect the membrane current density of inward-rectifier K+ channels (Kir2.1; encoded by KCNJ2) and profoundly alter the action potential shape of excitable ...
Swarnali Sengupta, Katheryn E. Rothenberg, Hanjun Li, Brenton D. Hoffman, Nenad Bursac   +4 more
openaire   +2 more sources

Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the trans-Golgi Network in COS-7 Cells

Frontiers in Physiology, 2018
The inward rectifying potassium channel, Kir2.1, is selected as cargo at the trans-Golgi network (TGN) for export to the cell surface through a unique signal-dependent interaction with the AP1 clathrin-adaptor, but it is unknown how the channel is ...
Tarvinder K. Taneja, Donghui Ma, Bo Y. Kim, Paul A. Welling   +3 more
doaj   +1 more source

Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome

bioRxiv, 2023
Background Andersen-Tawil Syndrome Type 1 (ATS1) is a rare heritable disease caused by mutations in the strong inwardly rectifying K+ channel Kir2.1. The extracellular Cys122-to-Cys154 disulfide bond in the Kir2.1 channel structure is crucial for proper ...
F. M. Cruz, Á. Macías, A. Moreno-Manuel, L. Gutierrez, M. L. Vera-Pedrosa, I. Martínez-Carrascoso, Patricia Sánchez Pérez, Juan Manuel Ruiz Robles, F. Bermúdez-Jiménez, Aitor Díaz-Agustín, Fernando Martínez de Benito, Salvador Arias Santiago, Aitana Braza-Boils, M. Martín-Martínez, M. Gutiérrez-Rodríguez, J. A. Bernal, E. Zorio, J. Jiménez-Jáimez, J. Jalife   +18 more
semanticscholar   +1 more source

Expression and contributions of the Kir2.1 inward-rectifier K+ channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states

Frontiers in Cellular Neuroscience, 2015
When microglia respond to CNS damage, they can range from pro-inflammatory (classical, M1) to anti-inflammatory, alternative (M2) and acquired deactivation states.
Doris eLam, Lyanne eSchlichter
doaj   +1 more source

Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets. [PDF]

PLoS Computational Biology, 2017
Plasma insulin oscillations are known to have physiological importance in the regulation of blood glucose. In insulin-secreting β-cells of pancreatic islets, K(ATP) channels play a key role in regulating glucose-dependent insulin secretion.
Vehpi Yildirim, Suryakiran Vadrevu, Benjamin Thompson, Leslie S Satin, Richard Bertram   +4 more
doaj   +1 more source

Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

eLife, 2022
A long-standing goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships to understand how mutations cause disease.
Willow Coyote-Maestas, David Nedrud, Yungui He, Daniel Schmidt   +3 more
doaj   +1 more source

Kir2.1 channel regulates macrophage polarization via Ca2+/CaMK II/ERK/NF-κB signaling pathway.

Journal of Cell Science, 2022
Macrophage polarization plays a key role in inflammatory response. Various ion channels expressed in macrophages has been documented, but very little is known about their roles in macrophage polarization.
Kuihao Chen, Qiaoyan Man, Jiaen Miao, Wenjing Xu, Yangchen Zheng, Xiuli Zhou, Zhe Gao   +6 more
semanticscholar   +1 more source