Results 51 to 60 of about 5,909 (195)

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

eLife, 2018
We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal. We
Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson   +3 more
doaj   +1 more source

Defective Potassium Channel Kir2.1 Trafficking Underlies Andersen-Tawil Syndrome [PDF]

Journal of Biological Chemistry, 2003
Andersen-Tawil syndrome is a skeletal and cardiac muscle disease with developmental features caused by mutations in the inward rectifier K+ channel gene KCNJ2. Patients harboring these mutations exhibit extremely variable expressivities. To explore whether these mutations can be correlated with a specific patient phenotype, we expressed both wild-type (
Saïd, Bendahhou, Matthew R, Donaldson, Nikki M, Plaster, Martin, Tristani-Firouzi, Ying-Hui, Fu, Louis J, Ptácek   +5 more
openaire   +2 more sources

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

Frontiers in Pharmacology, 2022
The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death.
C. Du, R. Rasmusson, G. Bett, Brandon Franks, Henggui Zhang, J. Hancox   +5 more
semanticscholar   +1 more source

Membrane Hyperpolarization Induced by Endoplasmic Reticulum Stress Facilitates Ca2+ Influx to Regulate Cell Cycle Progression in Brain Capillary Endothelial Cells

Journal of Pharmacological Sciences, 2014
.: Upregulation of the Kir2.1 channel during endoplasmic reticulum (ER) stress in t-BBEC117, an immortalized bovine brain endothelial cell line, caused a sustained increase in intracellular Ca2+ concentration ([Ca2+]i) and a facilitation of cell death ...
Hiroaki Kito, Hisao Yamamura, Yoshiaki Suzuki, Susumu Ohya, Kiyofumi Asai, Yuji Imaizumi   +5 more
doaj   +1 more source

Differential effects of obesity on visceral vs. subcutaneous adipose arteries: role of shear activated Kir2.1 and alterations to the glycocalyx.

American Journal of Physiology. Heart and Circulatory Physiology, 2021
Obesity imposes well-established deficits to endothelial function. We recently showed that obesity-induced endothelial dysfunction was mediated by disruption of the glycocalyx and a loss of Kir channel flow-sensitivity.
S. J. Ahn, Elizabeth Le Master, James C. Lee, S. Phillips, I. Levitan, Ibra S. Fancher   +5 more
semanticscholar   +1 more source

Decrease in an Inwardly Rectifying Potassium Conductance in Mouse Mammary Secretory Cells after Forced Weaning. [PDF]

PLoS ONE, 2015
Mammary glands are physiologically active in female mammals only during nursing. Immediately after weaning, most lactation-related genes are downregulated and milk production ceases.
Akihiro Kamikawa, Shota Sugimoto, Osamu Ichii, Daisuke Kondoh   +3 more
doaj   +1 more source

Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration

International Journal of Molecular Sciences, 2021
(1) Background: As membrane channels contribute to different cell functions, understanding the underlying mechanisms becomes extremely important. A large number of neuronal channels have been investigated, however, less studied are the channels expressed
Ruxandra Anton, Mihail Ghenghea, V. Ristoiu, C. Gattlen, M. Suter, P. Cojocaru, A. Popa-Wagner, B. Cătălin, A. Deftu   +8 more
semanticscholar   +1 more source

Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1

Nature Cardiovascular Research, 2022
Andersen–Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of unknown mechanism. In this study, we generated and characterized a mouse model of ATS1 carrying the trafficking-deficient mutant Kir2.1Δ314-315 channel.
Á. Macías, A. González-Guerra, A. Moreno-Manuel, F. M. Cruz, L. Gutierrez, N. García-Quintáns, M. Roche-Molina, F. Bermúdez-Jiménez, V. Andrés, M. L. Vera-Pedrosa, I. Martínez-Carrascoso, J. A. Bernal, J. Jalife   +12 more
semanticscholar   +1 more source

Empagliflozin and Dapagliflozin Increase Na⁺ and Inward Rectifier K⁺ Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Cells, 2022
Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients.
María Dago, Teresa Crespo-García, Anabel Cámara-Checa, Josu Rapún, Marcos Rubio-Alarcón, María Marín, Juan Tamargo, Ricardo Caballero, Eva Delpón   +8 more
doaj   +1 more source

Energetics and Location of Phosphoinositide Binding in Human Kir2.1 Channels [PDF]

Journal of Biological Chemistry, 2013
Kir2.1 channels are uniquely activated by phosphoinositide 4,5-bisphosphate (PI(4,5)P2) and can be inhibited by other phosphoinositides (PIPs). Using biochemical and computational approaches, we assess PIP-channel interactions and distinguish residues that are energetically critical for binding from those that alter PIP sensitivity by shifting the open-
Nazzareno, D'Avanzo, Sun-Joo, Lee, Wayland W L, Cheng, Colin G, Nichols   +3 more
openaire   +2 more sources