Results 61 to 70 of about 5,909 (195)

Expression of Kir2.1 Channels in Astrocytes Under Pathophysiological Conditions

Molecules and Cells, 2008
Astrocyte ion channels participate in ionic homeostasis in the brain. Inward rectifying potassium channels (Kir channels) in astrocytes have been particularly implicated in K(+) homeostasis because of their high open probability at resting potential and their increased conductance at high concentrations of extracellular K(+). We examined the expression
Shin Jung, Kang, Sang-Hee, Cho, Kyungjoon, Park, Jihyun, Yi, Soon Ji, Yoo, Ki Soon, Shin   +5 more
openaire   +2 more sources

Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion

Molecular Pain, 2010
Background A chronic compressed dorsal root ganglion (CCD) in rat produces pain behavior and an enhanced excitability of neurons within the compressed ganglion.
Johns David C, Zhang Pu, Rosenzweig Jason, Ma Chao, LaMotte Robert H   +4 more
doaj   +1 more source

Hypoxia inhibits the cardiac IK1 current through SUMO targeting Kir2.1 activation by PIP2

iScience, 2022
Summary: Cardiovascular diseases remain the leading cause of death worldwide. Most deaths are sudden and occur secondary to the occlusion of coronary arteries resulting in a rapid decrease in cellular oxygen levels.
Yu Xu, Yuchen Yang, Aishwarya Chandrashekar, Kirin D. Gada, Meghan Masotti, Austin M. Baggetta, Jenna G. Connolly, Takeharu Kawano, Leigh D. Plant   +8 more
doaj   +1 more source

Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

Signal Transduction and Targeted Therapy, 2022
Medulloblastoma (MB) is one of the most common childhood malignant brain tumors (WHO grade IV), traditionally divided into WNT, SHH, Group 3, and Group 4 subgroups based on the transcription profiles, somatic DNA alterations, and clinical outcomes ...
Yan-xia Wang, Hai-bo Wu, Yong-ya Ren, Shengqing Lv, Cheng-dong Ji, D. Xiang, Meng-si Zhang, Huimin Lu, Wen-juan Fu, Qing Liu, Zexuan Yan, Qing-hua Ma, Jing-ya Miao, Ruili Cai, X. Lan, Bin Wu, Wen-ying Wang, Yinhua Liu, Dai-zhong Wang, Mian-fu Cao, Zhi-cheng He, Yu Shi, Y. Ping, X. Yao, Xia Zhang, Peng Zhang, Ji Ming Wang, Yan Wang, You-hong Cui, X. Bian   +29 more
semanticscholar   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration

International Journal of Molecular Medicine, 2022
The investigation of effective therapeutic drugs for pulmonary hypertension (PH) is critical. KIR2.1 plays crucial roles in regulating cell proliferation and migration, and vascular remodeling. However, researchers have not yet clearly determined whether
Nan Cao, Nigala Aikeremu, Wen-yan Shi, Xuechun Tang, Rui-juan Gao, L. Kong, Jingrong Zhang, Wenjuan Qin, Aimei Zhang, K. Ma, Li Li, J. Si   +11 more
semanticscholar   +1 more source

Cellular and molecular cross‐talk in atrial fibrillation: The role of non‐cardiomyocytes in creating an arrhythmogenic substrate

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of cellular and molecular cross‐talk in atrial fibrillation. Left: a schematic of cardiac tissue showing cardiomyocytes, fibroblasts, adipocytes, inflammatory cells and the coagulation system. Right: direct and indirect cross‐talk between different cell types, with the impact of direct cross‐talk on action potential (
Zhenyu Dong, Ruben Coronel, Joris R. de Groot   +2 more
wiley   +1 more source

Synaptic Scaffolds, Ion Channels and Polyamines in Mouse Photoreceptor Synapses: Anatomy of a Signaling Complex

Frontiers in Cellular Neuroscience, 2021
Synaptic signaling complexes are held together by scaffold proteins, each of which is selectively capable of interacting with a number of other proteins.
Alejandro Vila, Alejandro Vila, Eyad Shihabeddin, Eyad Shihabeddin, Zhijing Zhang, Abirami Santhanam, Christophe P. Ribelayga, Christophe P. Ribelayga, John O’Brien, John O’Brien   +9 more
doaj   +1 more source

Variable Clinical Appearance of the Kir2.1 Rare Variants in Russian Patients with Long QT Syndrome

Genes, 2022
Background: The KCNJ2 gene encodes inward rectifier Kir2.1 channels, maintaining resting potential and cell excitability. Presumably, clinical phenotypes of mutation carriers correlate with ion permeability defects. Loss-of-function mutations lead to QTc
E. Zaklyazminskaya, M. Polyak, A. Shestak, M.A. Sadekova, V. Komoliatova, I. Kiseleva, L. Makarov, D. Podolyak, G. Glukhov, Han Zhang, D. Abramochkin, O. Sokolova   +11 more
semanticscholar   +1 more source