Results 71 to 80 of about 5,909 (195)
The Journal of Physiology, EarlyView.Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu +2 more
wiley +1 more source
Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation. [PDF]
PLoS ONE, 2013 Estrogen deficiency is associated with increased incidence of cardiovascular diseases. But merely estrogen supplementary treatment can induce many severe complications such as breast cancer.
Ying Zhang +14 more
doaj +1 more source
Disease Markers, 2022 Aim To explore the role of Kir2.1 in hypoxia-induced microglial apoptosis. Methods BV2 microglial cell lines were cultured and treated with ML133 hydrochloride, a Kir2.1 channel blocker, for 23 h and with 500 μmol/L of CoCl2 for 8 h.
Yunyi Xie +9 more
semanticscholar +1 more source
The inward rectifier potassium channel Kir2.1 is required for osteoblastogenesis [PDF]
Human Molecular Genetics, 2014 Andersen's syndrome (AS) is a rare and dominantly inherited pathology, linked to the inwardly rectifying potassium channel Kir2.1. AS patients exhibit a triad of symptoms that include periodic paralysis, cardiac dysrhythmia and bone malformations.
Sonia, Sacco +6 more
openaire +2 more sources
14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses
The Journal of Physiology, EarlyView.Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley +1 more source
Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.
PLoS ONE, 2016 BackgroundCardiac inwardly rectifying Kir current (IK1) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential.
Daniel Scherer +10 more
doaj +1 more source
eLife, 2022 Background: Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown.
Eric N Jimenez-Vazquez +13 more
doaj +1 more source
Effects of Ruanmailing in Blocking Early Stages of Atherosclerosis by TNF-α Regulation via Kir2.1
Evidence-Based Complementary and Alternative Medicine, 2022 Objective Ruanmailing oral solution consists of 16 herbs, has anti-lipid peroxidation activity, protects vascular endothelial cells, and improves vascular elasticity. It is an effective drug for the treatment of atherosclerosis (AS).
Liufang Fan +6 more
semanticscholar +1 more source
ESCRT regulates surface expression of the Kir2.1 potassium channel
Molecular Biology of the Cell, 2014 Protein quality control (PQC) is required to ensure cellular health. PQC is recognized for targeting the destruction of defective polypeptides, whereas regulated protein degradation mechanisms modulate the concentration of specific proteins in concert with physiological demands. For example, ion channel levels are physiologically regulated within tight
Kolb, Alexander R. +5 more
openaire +2 more sources
Voltage Dependence of Kir2.1 Block by Intracellular Spermine [PDF]
Biophysical Journal, 2010 Strong voltage sensitivity of inward-rectifier K+ (Kir) channels, such as Kir2.1, has been hypothesized to arise primarily from an intracellular spermine molecule displacing K+ ions from the wide, intracellular part of the ion conduction pore outwardly across the narrow ion selectivity filter.
Shin, Hyeon-Gyu, Xu, Yanping, Lu, Zhe
openaire +1 more source