Results 81 to 90 of about 5,909 (195)
The Journal of Physiology, EarlyView.Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera +6 more
wiley +1 more source
Domain insertion permissibility-guided engineering of allostery in ion channels
Nature Communications, 2019 Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a ...
Willow Coyote-Maestas +3 more
doaj +1 more source
Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients
BMC Medical Genetics, 2017 Background Mutations in the KCNJ2 gene encoding the ion channel Kir2.1 have been linked to the Andersen-Tawil syndrome (ATS). Molecular genetic screening performed in a family exhibiting clinical ATS phenotypes unmasked a novel sequence variant (c.434A >
Stefanie Scheiper +5 more
doaj +1 more source
Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3. [PDF]
PLoS ONE, 2009 BACKGROUND:Neurosteroids have various physiological and neuropsychopharmacological effects. In addition to the genomic effects of steroids, some neurosteroids modulate several neurotransmitter receptors and channels, such as N-methyl-D-aspartate ...
Toru Kobayashi +2 more
doaj +1 more source
Naunyn-Schmiedeberg's Archives of PharmacologyThe functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity.
E. Li, M. V. D. van der Heyden
semanticscholar +1 more source
Journal of Cerebral Blood Flow and Metabolism, 2022 Cerebral blood flow is a finely tuned process dependent on coordinated changes in arterial tone. These changes are strongly tied to smooth muscle membrane potential and inwardly rectifying K+ (KIR) channels are thought to be a key determinant.
Paulina M Kowalewska +10 more
semanticscholar +1 more source
Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels [PDF]
The Journal of Cell Biology, 2001 Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier.
Fischer-Lougheed, Jacqueline +6 more
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira +7 more
wiley +1 more source
Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits [PDF]
FEBS Letters, 2001 We have identified several cDNAs for the human Kir5.1 subunit of inwardly rectifying K+ channels. Alternative splicing of exon 3 and the usage of two alternative polyadenylation sites contribute to cDNA diversity. The hKir5.1 gene KCNJ16 is assigned to chromosomal region 17q23.1–24.2, and is separated by only 34 kb from the hKir2.1 gene (KCNJ2). In the
Derst, Christian +9 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source