Kappa Opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons [PDF]
, 2015 The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular and neural circuit mechanisms are not understood.
Bruchas, Michael R +9 more
core +3 more sources
Postsynaptic GABAB‐receptor mediated currents in diverse dentate gyrus interneuron types
Hippocampus, Volume 34, Issue 10, Page 551-562, October 2024.Abstract The processing of rich synaptic information in the dentate gyrus (DG) relies on a diverse population of inhibitory GABAergic interneurons to regulate cellular and circuit activity, in a layer‐specific manner. Metabotropic GABAB‐receptors (GABABRs) provide powerful inhibition to the DG circuit, on timescales consistent with behavior and ...
Claudius E. Degro +2 more
wiley +1 more source
Toward the language oscillogenome [PDF]
, 2018 Language has been argued to arise, both ontogenetically and phylogenetically, from specific patterns of brain wiring. We argue that it can further be shown that core features of language processing emerge from particular phasal and cross-frequency ...
Benítez Burraco, Antonio +1 more
core +2 more sources
Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins [PDF]
The Journal of Physiology, 2007 Many neurotransmitters and hormones signal by stimulating G protein‐coupled neurotransmitter receptors (GPCRs), which activate G proteins and their downstream effectors. Whether these signalling proteins diffuse freely within the plasma membrane is not well understood. Recent studies have suggested that direct protein–protein interactions exist between
Catherine E, Fowler +3 more
openaire +2 more sources
The roles of RGS proteins in cardiometabolic disease
British Journal of Pharmacology, Volume 181, Issue 14, Page 2319-2337, July 2024.G protein‐coupled receptors (GPCRs) are the most prominent receptors on the surface of the cell and play a central role in the regulation of cardiac and metabolic functions. GPCRs transmit extracellular stimuli to the interior of the cells by activating one or more heterotrimeric G proteins.
Samantha M. McNeill, Peishen Zhao
wiley +1 more source
Involvement of Protein Kinase C and Protein Kinase A in the Enhancement of L-type Calcium Current by GABA\u3csub\u3eB\u3c/sub\u3e Receptor Activation in Neonatal Hippocampus [PDF]
, 2011 In the early neonatal period activation of GABAB receptors attenuates calcium current through N-type calcium channels while enhancing current through L-type calcium channels in rat hippocampal neurons.
Bray, Jennifer Grace, Mynlieff, Michelle
core +1 more source
The source of SYBR green master mix determines outcome of nucleic acid amplification reactions [PDF]
, 2016 Numerous real-time PCR devices and master mixes are available on the market. To perform reliable high-quality data, PCR master mix, and equipment need to be optimal.
Berit Kemps-Mols +5 more
core +3 more sources
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia
BioFactors, Volume 50, Issue 3, Page 523-541, May/June 2024.The inward rectifying K+ channel Kir2.1 plays a major role in extracellular potassium buffering in the brain. Here we show that in cellular models of aging neuroglia characterized by an elevated oxidative stress, the Kir2.1‐induced current is dramatically reduced. This loss of function resulted from a reduction in protein abundance, with no alterations
Alessia Remigante +7 more
wiley +1 more source
p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate [PDF]
, 2008 The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood.
Bartlett, P. F. +7 more
core +1 more source
The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels [PDF]
, 2002 Approximately half of the NH(2) terminus of inward rectifier (Kir) channels can be deleted without significant change in channel function, but activity is lost when more than ∼30 conserved residues before the first membrane spanning domain (M1) are ...
Cukras, Catherine A +2 more
core +3 more sources