Results 71 to 80 of about 1,352 (160)

Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels

Etude computationnelle de la relation structure-fonction des canaux Kir3 et application dans la conception de canaux Kir3 sensibles à la lumière Cette thèse de doctorat porte sur une famille de protéines transmembranaires exprimées sous forme de tétramères qui fonctionnent en tant que canaux ioniques sélectifs pour le potassium - le ...
openaire   +2 more sources

Neuronal Inwardly Rectifying K⁺Channels Differentially Couple to PDZ Proteins of the PSD-95/SAP90 Family

, 2000
Several signaling proteins clustered at the postsynaptic density specialization in neurons harbor a conserved C-terminal PDZ domain recognition sequence (X-S/T-X-V/I) that mediates binding to members of the PSD-95/SAP90 protein family. This motif is also
Ralf B. Nehring, Andreas Karschin, Frank Döring, Rüdiger W. Veh, Erhard Wischmeyer, Morgan Sheng   +5 more
core   +1 more source

G-protein mediated trafficking of inwardly rectifying potassium channels [PDF]

, 2008
Understanding the mechanisms which regulate trafficking and surface expression of membrane-associated proteins is crucial to understanding their function in a physiological context.
Boyer, Stephanie B.
core  

Differenzielle Verteilung von GABAB Rezeptoren, Kir3 und Cav2 Ionenkanälen in Parvalbumin und Cholecystokinin exprimierenden Interneuronen des Hippocampus

, 2012
Kortikale neuronale Aktivität unterliegt der präzisen Kontrolle eines heterogenen Netzwerkes inhibitorischer GABAerger Interneurone. Parvalbumin- (PV) und Cholecystokinin- (CCK) exprimierende (+) Neurone übernehmen eine Schlüsselfunktion bei der ...
Althof, Daniel
core  

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q Correspondence

, 2020
BACKGROUND G protein-coupled inwardly rectifying potassium (KIR3) channels are important proteins that regulate numerous physiological processes including excitatory responses in the CNS and the control of heart rate.
Tin T Yow, Mary Chebib, Nathan Absalom, Jane R Hanrahan, Graham Ar Johnston, Elena Pera, Marika Heblinski   +6 more
core  

Principle of the electrophysiological characterization of chemokine receptors.

, 2014
A. Receptors and channels are expressed in Xenopus laevis oocytes by mRNA micro-injection. After 2 day-incubation, purified chemokines are electrophysiologically characterized. B.
Lina Šiaučiūnaiteė-Gaubard (517703), Franck Fieschi (296308), Rabia Sadir (35737), Lydia Caro (517705), Michel Vivaudou (141672), Isabelle Petit-Hartlein (517704), Antoine Picciocchi (76735), Christophe Moreau (517706), Corinne Vivès (517707), Jean Revilloud (226552)   +9 more
core   +1 more source

Inwardly rectifying potassium channels (K_IR) in GtoPdb v.2025.4 [PDF]

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G protein-activated inward-rectifier K channels (Kir3.x)
Tucker, Stephen, Lazdunski, Michel, Jan, Lily Y., Kubo, Yoshihiro, Slesinger, Paul A., Nichols, Colin G., Clapham, David E, Pearson, Wade L, Adelman, John P, Karschin, Andreas, Pearson, Wade L., Slesinger, Paul A, Vandenberg, Carol A., Miki, Takashi, Adelman, John P., Seino, Susumu, Nichols, Colin G, Palmer, Lawrence G., Palmer, Lawrence G, Jan, Lily Y, Kurachi, Yoshihisa, Inanobe, Atsushi, Hibino, Hiroshi, Vandenberg, Carol A, Clapham, David E., Sackin, Henry   +25 more
core   +1 more source

Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.3 [PDF]

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x)
Vandenberg, Carol A., Tucker, Stephen, Lazdunski, Michel, Adelman, John P., Miki, Takashi, Seino, Susumu, Jan, Lily Y., Slesinger, Paul A., Palmer, Lawrence G., Kubo, Yoshihiro, Nichols, Colin G., Kurachi, Yoshihisa, Inanobe, Atsushi, Hibino, Hiroshi, Clapham, David E., Karschin, Andreas, Sackin, Henry, Pearson, Wade L.   +17 more
core   +1 more source

Opioide bei neuropathischen Schmerzen - die Rolle von Kaliumkanälen in primären sensorischen Neuronen

, 2018
Neuropathic pain is a debilitating condition often arising from damage to peripheral nerves.Patients suffer from spontaneous pain and pain evoked by thermal / mechanical stimuli. The underlying pathophysiology is complex and poorly understood.
Stötzner, Philip
core   +1 more source

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels: Molecular, cellular, and subcellular diversity.

Histology and histopathology
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels are mainly expressed in excitable cells such as neurons and atrial myocytes, where they can respond to a wide variety of neurotransmitters. Four GIRK subunits have been found in mammals (GIRK1-4) and act as downstream targets for various Gαi/o-linked G protein-coupled receptors (GPCRs ...
Martín Belmonte, Alejandro, Aguado Rubio, Carolina, Alfaro Ruiz, Rocío, Luján Miras, Rafael   +3 more
openaire   +3 more sources