Results 51 to 60 of about 1,352 (160)
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source
Compartmental distribution of GABA-B receptor-mediated currents along the somato-dendritic axis of hippocampal principal cells [PDF]
, 2015 Activity of cortical principal cells is controlled by the GABAergic system providing inhibition in a compartmentalized manner along their somatodendritic axis.
Sam A Booker +13 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
, 2013 The magnitudes of change in Kir currents by 100 µM PREGS were normalized to the 3 mM Ba2+-sensitive current components. For Kir3 channels, oocytes expressing brain-type Kir3.1/Kir3.2 channels were used.
Kazutaka Ikeda (142226) +2 more
core +1 more source
Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABA(B) receptors in hippocampal pyramidal cells [PDF]
, 2006 G-protein-coupled inwardly rectifying K+ channels (Kir3 channels) coupled to metabotropic GABAB receptors are essential for the control of neuronal excitation.
Vida, Imre +11 more
core +1 more source
Specificity of Gβγ Signaling to Kir3 Channels Depends on the Helical Domain of Pertussis Toxin-sensitive Gα Subunits [PDF]
Journal of Biological Chemistry, 2007 Acetylcholine signaling through muscarinic type 2 receptors activates atrial G protein-gated inwardly rectifying K(+) (Kir3) channels via the betagamma subunits of G proteins (Gbetagamma). Different combinations of recombinant Gbetagamma subunits have been shown to activate Kir3 channels in a similar manner.
Radda, Rusinova +2 more
openaire +2 more sources
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley +1 more source
Gating of GIRK Channels Details of an Intricate, Membrane-Delimited Signaling Complex [PDF]
, 2003 G protein-coupled inwardly rectifying potassium channels (GIRK/Kir3) are important elements in controlling cellular excitability. In recent years, tremendous progress has been made toward understanding various components involved in channel activation ...
Alagem, Noga +2 more
core +1 more source
Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins [PDF]
The Journal of Physiology, 2007 Many neurotransmitters and hormones signal by stimulating G protein‐coupled neurotransmitter receptors (GPCRs), which activate G proteins and their downstream effectors. Whether these signalling proteins diffuse freely within the plasma membrane is not well understood. Recent studies have suggested that direct protein–protein interactions exist between
Catherine E, Fowler +3 more
openaire +2 more sources
ChemMedChem, Volume 20, Issue 13, July 1, 2025.Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid +8 more
wiley +1 more source