Results 31 to 40 of about 1,352 (160)

The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels [PDF]

Channels, 2010
Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events.
Peter, Zylbergold, Nitya, Ramakrishnan, Terence, Hebert   +2 more
openaire   +2 more sources

Decreased Cocaine Self-Administration in Kir3 Potassium Channel Subunit Knockout Mice [PDF]

Neuropsychopharmacology, 2002
Multiple G protein-linked neurotransmitter systems have been implicated in the behavioral effects of cocaine. While actions of certain neurotransmitter receptor subtypes and transporters have been identified, the role of individual G protein-regulated enzymes and ion channels in the effects of cocaine remains unclear. Here, we assessed the contribution
Andrew D, Morgan, Marilyn E, Carroll, Annemarie K, Loth, Markus, Stoffel, Kevin, Wickman   +4 more
openaire   +2 more sources

G Protein βγ Gating Confers Volatile Anesthetic Inhibition to Kir3 Channels [PDF]

Journal of Biological Chemistry, 2010
G protein-activated inwardly rectifying potassium (GIRK or Kir3) channels are directly gated by the βγ subunits of G proteins and contribute to inhibitory neurotransmitter signaling pathways. Paradoxically, volatile anesthetics such as halothane inhibit these channels. We find that neuronal Kir3 currents are highly sensitive to inhibition by halothane.
Amanda M, Styer, Uyenlinh L, Mirshahi, Chuan, Wang, Laura, Girard, Taihao, Jin, Diomedes E, Logothetis, Tooraj, Mirshahi   +6 more
openaire   +2 more sources

Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2022
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x)
Slesinger, Paul A, Lazdunski, Michel, Tucker, Stephen, Miki, Takashi, Nichols, Colin G, Seino, Susumu, Kubo, Yoshihiro, Palmer, Lawrence G, Clapham, David E, Pearson, Wade L, Jan, Lily Y, Inanobe, Atsushi, Kurachi, Yoshihisa, Adelman, John P, Hibino, Hiroshi, Vandenberg, Carol A, Karschin, Andreas, Sackin, Henry   +17 more
core   +2 more sources

Kir3-Based Inward Rectifier Potassium Current [PDF]

Circulation, 2006
Background—We previously characterized a novel K+current (IKH) with properties of constitutively active acetylcholine-related current in dog atrium.IKHis sensitive to tertiapin-Q (IC50≈10 nmol/L), a highly selective Kir3 current blocker. This study assessed the role ofIKHin atrial tachycardia (AT)–remodeled canine left atrium (LA) with the use of ...
Tae-Joon, Cha, Joachim R, Ehrlich, Denis, Chartier, Xiao-Yan, Qi, Ling, Xiao, Stanley, Nattel   +5 more
openaire   +2 more sources

Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to Drosophila melanogaster. [PDF]

Insects
Inwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides.
Liu X, Gao Y, Liu T, Guo H, Qiao J, Su J.   +5 more
europepmc   +2 more sources

Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability [PDF]

Neuropsychopharmacology, 2017
Alcohol abuse disorders are associated with dysfunction of frontal cortical areas including the orbitofrontal cortex (OFC). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, including alcoholism.
Sudarat, Nimitvilai, Marcelo F, Lopez, Patrick J, Mulholland, John J, Woodward   +3 more
openaire   +2 more sources

Heterogeneous distribution of Kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain [PDF]

, 2001
0 Titelblatt und Inhaltsverzeichnis 1 Einleitung 8 1.1 Ionenkanäle 8 1.2 Kaliumkanäle 8 1.3 Einwärtsgleichrichtende Kaliumkanäle (Kir-Kanäle) 11 1.4 Kir3-Kanäle 14 1.5 Basalganglien und ventrales Mesencephalon 18 ...
Eulitz, Dirk
core   +1 more source

Signal transduction pathway for the substance P‐induced inhibition of rat Kir3 (GIRK) channel [PDF]

The Journal of Physiology, 2005
Certain transmitters inhibit Kir3 (GIRK) channels, resulting in neuronal excitation. We analysed signalling mechanisms for substance P (SP)‐induced Kir3 inhibition in relation to the role of phosphatidylinositol 4,5‐bisphosphate (PIP2). SP rapidly – with a half‐time of ∼10 s with intracellular GTPγS and ∼14 s with intracellular GTP – inhibits a ...
Maki, Koike-Tani, John M, Collins, Takeharu, Kawano, Peng, Zhao, Qi, Zhao, Tohru, Kozasa, Shigehiro, Nakajima, Yasuko, Nakajima   +7 more
openaire   +2 more sources

Dominant negative effects of a Gβ mutant on G-protein coupled inward rectifier K+ channel [PDF]

, 2006
HEK293 cells were transfected with cDNAs for Gβ1(W332A) [a mutant Gβ1], Gγ2, and inward rectifier K+ channels (Kir3.1/Kir3.2). Application of Gβ1γ2 protein to these cells activated the K+ channels only slightly. When mu-opioid receptors and Kir3.1/Kir3.2
Zhao, Qi, Albsoul-Younes, Abla M., Qi Zhao, Kozasa, Tohru, Nakajima, Shigehiro, Abla M. Albsoul-Younes, Peng Zhao, Shigehiro Nakajima, Zhao, Peng, Nakajima, Yasuko, Tohru Kozasa, Yasuko Nakajima   +11 more
core   +1 more source