Kir3 channel signaling complexes: Focus on opioid receptor signaling [PDF]
Frontiers in Cellular Neuroscience, 2014 Opioids are among the most effective drugs to treat severe pain. They produce their analgesic actions by specifically activating opioid receptors located along the pain perception pathway where they inhibit the flow of nociceptive information.
Karim eNagi +3 more
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Kir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking. [PDF]
Frontiers in Cellular Neuroscience, 2014 The role of Gβγ subunits in Kir3 channel gating is well characterized. Here, we have studied the role of Gβγ dimers during their initial contact with Kir3 channels, prior to their insertion into the plasma membrane.
Peter eZylbergold +11 more
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Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses. [PDF]
Sci Rep, 2020 In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing.
Johansson F, Hesslow G.
europepmc +5 more sources
Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice [PDF]
The Journal of Neuroscience, 2008 Although morphine induces both analgesia and dependence through mu-opioid receptors (MORs), the respective contributions of the intracellular effectors engaged by MORs remain unknown. To examine the contribution of G-protein-gated inwardly rectifying K(+)
Luescher, Christian +6 more
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μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice. [PDF]
J PhysiolOpioid‐induced respiratory depression (OIRD) is mediated, in part, by μ‐opioid receptor (μOR) signalling in the respiratory rhythmogenic preBötzinger complex (preBötC). However, it has been unclear whether opioids affect excitatory or inhibitory neurons,
Kalajian EJ +3 more
europepmc +3 more sources
Modulation of Neuronal Kir3 Channels by Cholesterol [PDF]
Biophysical Journal, 2016 In recent years, cholesterol emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels is a decrease in channel activity. We have recently shown that unexpectedly cholesterol enrichment up-regulates G-protein gated inwardly rectifying potassium (GIRK or Kir3) activity in atrial myocytes.Here we focus on
Avia Rosenhouse-Dantsker, Anna N. Bukiya
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Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans [PDF]
Circulation, 2013 Background—Atrial fibrillation is the most common cardiac arrhythmia. Ventricular proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium-specific Kir3.x channels, which generate a constitutively active current (IK,ACh-c)
Bingen, Brian O +17 more
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Melatonin receptors activate heteromeric G-protein coupled Kir3 channels
NeuroReport, 1996 The effects of melatonin on circadian pacemaker activity in the central nervous system may be the result of melatonin receptor activation of G-protein coupled potassium channels which inhibit the action potential firing of neurons.
Allen, CN, Nelson, CS, Marino, JL
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Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury [PDF]
Frontiers in Pharmacology, 2018 Neuropathic pain often arises from damage to peripheral nerves and is difficult to treat. Activation of opioid receptors in peripheral sensory neurons is devoid of respiratory depression, sedation, nausea, and addiction mediated in the brain, and ...
Spahn, Viola +9 more
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Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes
Cellular Signalling, 2009 We have previously demonstrated that Kir3.1 channels and G beta 1 gamma 2 subunits initially interact in the endoplasmic reticulum (ER). To elucidate the role that anterograde protein trafficking pathways may play in the formation of these complexes, we ...
Ramakrishnan, Nitya +3 more
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