Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) [PDF]
Journal of Biological Chemistry, 2018 Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral tissues.
Hendon, T. +9 more
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Characterizing the roles of multiple Gbetagamma binding sites on Kir3 channels
, 2010 Kir3 channels contain multiple Gβγ binding sites within their N- and C-terminal domains. However, the channel opens when only a few binding sites are occupied by Gβγ, suggesting that some sites subserve roles other than agonist-dependent interactions. We
Ramakrishnan, Nitya
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A novel, radiolabel-free pulse chase strategy for studying Kir3-Gßy assembly and trafficking
, 2014 Kir3 channels are essential regulators of neuronal and cardiac excitability, maintaining cells at their resting membrane potentials. While much research has been dedicated to elucidating mechanisms by which signalling proteins regulate Kir3 channel ...
Zylbergold, Peter
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Mechanism of PLC-Mediated Kir3 Current Inhibition [PDF]
Channels, 2007 A large number of ion channels maintain their activity through direct interactions with phosphatidylinositol bisphosphate (PIP2). For such channels, hydrolysis of PIP2 causes current inhibition. It has become controversial whether the inhibitory effects on channel activity represent direct effects of PIP2 hydrolysis or of downstream PKC action.
Inna, Keselman +3 more
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A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels [PDF]
The Journal of Neuroscience, 2015 Inwardly rectifying potassium channels enforce tight control of resting membrane potential in excitable cells. The Kir3.2 channel, a member of the Kir3 subfamily of G-protein-activated potassium channels (GIRKs), plays several roles in the nervous system, including key responsibility in the GABABpathway of inhibition, in pain perception pathways via ...
Scott K. Adney +4 more
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Subunit-Specific Regulation of Kir3 Channels by Sorting nexin 27 [PDF]
Channels, 2007 G protein-gated inwardly rectifying potassium (Kir3) channels are involved in regulating membrane excitability in the brain. Kir3 channels have been shown to play a role in learning, analgesia and drug addiction. Little is known about the cell surface regulation of Kir3 channels. Using a proteomics approach, we recently discovered that sorting nexin 27
Rounak, Nassirpour, Paul A, Slesinger
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Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G [PDF]
, 2010 Les récepteurs couplés aux protéines G forment des complexes multimériques comprenant protéines G et effecteurs. Nous cherchons à caractériser de tels complexes comprenant les récepteurs opioïdes delta (DOR) et les canaux Kir3, qui nous sont d’intérêt vu
Richard-Lalonde, Mélissa
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Behavioral characterization of mice lacking GIRK/Kir3 channel subunits [PDF]
Genes, Brain and Behavior, 2008 G protein‐gated inwardly rectifying K+ (GIRK/Kir3) channels mediate the postsynaptic inhibitory effects of many neurotransmitters and drugs of abuse. The lack of drugs selective for GIRK channels has hindered our ability to study their contributions to behavior.
M, Pravetoni, K, Wickman
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Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels. [PDF]
Biochemistry, 2020 Tertiapin (TPN) is a 21 amino acid venom peptide from Apis mellifera that inhibits certain members of the inward rectifier potassium (Kir) channel family at a nanomolar affinity with limited specificity.
Patel D, Kuyucak S, Doupnik CA.
europepmc +3 more sources
An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients - A study of T cells and natural killer cells. [PDF]
Curr Res ImmunolMalignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of
Heldager Pedersen N +4 more
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