Results 101 to 110 of about 2,269 (179)
Emerging neurotrophic role of GABAB receptors in neuronal circuit development [PDF]
, 2013 The proper development of highly organized structures in the central nervous system is a complex process during which key events – neurogenesis, migration, growth, differentiation, and synaptogenesis – have to take place in an appropriate manner to ...
Christophe Porcher, Jean-Luc Gaiarsa
core +1 more source
Voltage sensitivity of dopamine D2-like receptors [PDF]
, 2011 G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core +1 more source
The FASEB Journal, 2012 Inward rectifying potassium (Kir) channels play key physiological roles in diverse cell types and may represent novel drug targets for disease. In cardiac myocytes, Kir channels contribute to the resting membrane potential and the late repolarization phase of the action potential.
Rene Raphemot +9 more
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Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels
Frontiers in PhysiologyIon channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Ha Nguyen +2 more
doaj +1 more source
The Journal of Physiology, 2014 Key points Rhythmic activity in the gamma frequency range (30–80 Hz) in the hippocampus is modulated by neurotransmitters such as serotonin, dopamine and histamine. Multiple different serotonin receptors are expressed in the hippocampus. Here we show that serotonin suppresses hippocampal gamma oscillations via activation of the receptor 5‐HT1A.
April, Johnston +2 more
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Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells [PDF]
, 2018 The coupling of GABAB receptors to G-protein-gated inwardly rectifying potassium (GIRK) channels constitutes an important inhibitory pathway in the brain.
Berton, Frédérique +4 more
core
Histology and histopathologyG protein-gated inwardly rectifying K+ (GIRK/Kir3) channels are mainly expressed in excitable cells such as neurons and atrial myocytes, where they can respond to a wide variety of neurotransmitters. Four GIRK subunits have been found in mammals (GIRK1-4) and act as downstream targets for various Gαi/o-linked G protein-coupled receptors (GPCRs ...
Martín Belmonte, Alejandro +3 more
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G protein gated potassium channels (GIRK/ Kir3) mediate the motor stimulatory effects of opiates
The FASEB Journal, 2008 Neuronal GIRK channels mediate the postsynaptic inhibitory effect of many neurotransmitters and drugs of abuse, including opioids. GIRK subunits are expressed in dopamine and GABA neurons of the VTA, a structure implicated in opioid‐induced behaviors. We measured the impact of genetic ablation of different GIRK subunits in mice on the motor stimulatory
Marco Pravetoni, Kevin Wickman
openaire +1 more source
, 2019 This doctoral thesis focuses on a family of transmembrane proteins expressed as tetrameric assemblies which function as selective potassium ion channels – the potassium inward rectifier member 3 (Kir3). In the sub-family, four genes coding Kir3 proteins are present in mammals, namely, members Kir3.1 4.
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, 2016 Cholecystokinin-expressing interneurons (CCK-INs) mediate behavior state-dependent inhibition in cortical circuits and themselves receive strong GABAergic input.
Andrea Varro +20 more
core +2 more sources