Results 121 to 130 of about 1,352 (160)

The Role of K_ACh Channels in Atrial Fibrillation. [PDF]

Cells
Mitrokhin V, Hadzi-Petrushev N, Kazanski V, Schileyko S, Kamkina O, Rodina A, Zolotareva A, Zolotarev V, Kamkin A, Mladenov M.   +9 more
europepmc   +1 more source

Role of GIRK2 channels in morphine-induced metabolite changes in the rostral ventromedial medulla. [PDF]

Magn Reson Imaging
Dehkordi O, Lin S, Mohamud SF, Davila-Garcia M, Millis RM, Wang PC.   +5 more
europepmc   +1 more source

Evidence for M2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs. [PDF]

Invest Ophthalmol Vis Sci
Zhou H, Zhou G, Yang Q, Niu J, Wang R, Liu H, Hou S, Bi H, Liao X.   +8 more
europepmc   +1 more source

Conserved Kir channel mechanisms governing intrinsic excitability in human and rodent parvalbumin neurons. [PDF]

Commun Biol
Furdan S, Douida A, Bakos E, Tiszlavicz Á, Nemes K, Pongor LS, Péli K, Molnar G, Tamas G, Welter D, Landry J, H Kovács B, Erdélyi M, Bende B, Hutoczki G, Papp A, Barzo P, Benes V, Szucs A, Szegedi V, Lamsa K.   +20 more
europepmc   +1 more source

The crucial role of potassium ion channels in diabetes mellitus and its complications: A review. [PDF]

Channels (Austin)
Yang X, Yang Y.
europepmc   +1 more source

Potassium channel-targeted therapy in reducing vascular complications in diabetes mellitus: novel insights. [PDF]

Front Pharmacol
Rajkovic J, Ribic A, Rekovic L, Gostimirovic M, Bukarica A, Terzic D, Gojkovic-Bukarica L.   +6 more
europepmc   +1 more source

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Kir3 channel signalling complexes in cardiac arrhythmias

Drug Discovery Today: Disease Models, 2012
G protein-modulated inwardly rectifying potassium channels (Kir3, GIRK) are crucial integrators of G protein-coupled receptor (GPCR) signalling and play key roles in the stabilization of resting membrane potential in excitable and non-excitable cells. Here we discuss their roles in the heart, with a specific focus on how they might be involved in two ...
Peter Zylbergold, Terence E. Hébert
openaire   +1 more source

Chloroform is a potent activator of cardiac and neuronal Kir3 channels

Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
Chloroform has been used over decades in anesthesia before it was replaced by other volatile anesthetics like halothane or sevoflurane. Some of the reasons were inadmissible side effects of chloroform like bradycardia or neural illness. In the present study, we identified members of the G protein-activated inwardly rectifying potassium channel family ...
Sina, Kollert, Frank, Döring, Ulrich, Gergs, Erhard, Wischmeyer   +3 more
openaire   +2 more sources

Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides

International Review of Neurobiology, 2015
The question that started with the pioneering work of Otto Loewi in the 1920s, to identify how stimulation of the vagus nerve decreased heart rate, is approaching its 100th year anniversary. In the meantime, we have learned that the neurotransmitter acetylcholine acting through muscarinic M2 receptors activates cardiac potassium (Kir3) channels via the
Scott K Adney, Diomedes E Logothetis, Meng Cui   +2 more
exaly   +3 more sources