Results 81 to 90 of about 2,269 (179)

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source

Artificial Compartments Encapsulating Enzymatic Reactions: Towards the Construction of Artificial Organelles

ChemPlusChem, Volume 90, Issue 2, February 2025.
This review article summarizes the cellular compartments, and the current progress of artificial compartments constructed by using liposomes, polymersomes, proteins, nucleic acids, and hybrid materials. The perspectives for the future development of artificial compartments towards the construction of artificial organelles or cells were discussed ...
Peng Lin, Shiwei Zhang, Futa Komatsubara, Hiroaki Konishi, Eiji Nakata, Takashi Morii   +5 more
wiley   +1 more source

Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein βγ subunits [PDF]

Proceedings of the National Academy of Sciences, 2000
G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity. Because G protein βγ subunits containing either β1 or β2 with multiple Gγ subunits activate GIRK channels, we hypothesized that specificity ...
Q, Lei, M B, Jones, E M, Talley, A D, Schrier, W E, McIntire, J C, Garrison, D A, Bayliss   +6 more
openaire   +2 more sources

Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation

Andrology, Volume 13, Issue 2, Page 184-201, February 2025.
Abstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart   +3 more
wiley   +1 more source

Maize Combined Insect Resistance Genomic Regions and Their Co-localization With Cell Wall Constituents Revealed by Tissue-Specific QTL Meta-Analyses

Frontiers in Plant Science, 2018
Combinatorial insect attacks on maize leaves, stems, and kernels cause significant yield losses and mycotoxin contaminations. Several small effect quantitative trait loci (QTL) control maize resistance to stem borers and storage pests and are correlated ...
Arfang Badji, Michael Otim, Lewis Machida, Thomas Odong, Daniel Bomet Kwemoi, Dennis Okii, Symphorien Agbahoungba, Natasha Mwila, Frank Kumi, Angele Ibanda, Stephen Mugo, Samuel Kyamanywa, Patrick Rubaihayo   +12 more
doaj   +1 more source

The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective. [PDF]

, 2006
In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies.
Barnes, Baron, Baron, Baron, Baron, Baron, Baron, Beelen, Birkeland, Bishara, Bleakley, Bornhauser, Bortin, Burnet, Burnet, Burroughs, Caligiuri, Chien, Childs, Collins, Coscia, Davies, Diaconescu, Dunn, Dunn, Ehrlich, Engels, Feinstein, Fischer, Frohn, Frédéric Baron, Fukuda, Georges, Giebel, Giralt, Groh, Hegenbart, Herberman, Heslop, Hogan, Horowitz, Hsu, Hsu, Junghanss, Kaplan, Keating, Kerbauy, Khouri, Kolb, Kolb, Kolb, Köhler, Leung, Linenberger, Little, Livnat, Lokhorst, Maloney, Maloney, Maraninchi, Maris, Maris, Martin, Mathe, McSweeney, Mielcarek, Miller, Mohty, Molldrem, Moretta, Moretta, Morris, Morris, Niederwieser, Pagel, Pagel, Parham, Parikh, Peggs, Raff, Raff, Rainer Storb, Reff, Rosenberg, Rossig, Ruggeri, Sandmaier, Schwartz, Scott, Shankaran, Shilling, Sievers, Slavin, Smyth, Sorror, Sorror, Storb, Storb, Stutman, Sullivan, Sullivan, Thomas, Thomas, Timmerman, Walter, Weiden, Weiden, Weissinger, Wilson   +108 more
core   +1 more source

Cardiac Potassium Channels: Physiological Insights for Targeted Therapy. [PDF]

, 2017
The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that ...
A. John Camm, Christopher L.-H. Huang, Feng J, Hansen RS, Kamalan Jeevaratnam, Karan R. Chadda, Lepran I, Milnes JT, Nichols CG, Rampe D, Rampe D, Shieh CC, Wang Z, Zhao X, Zhou J   +14 more
core   +1 more source

KCNJ3 is a novel candidate gene for autosomal dominant pure hereditary spastic paraplegia identified using whole genome sequencing

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 195, Issue 7, October 2024.
Abstract Hereditary spastic paraplegia (HSP) is a group of familial diseases characterized by progressive corticospinal tract degeneration. Clinically, patients present with lower‐limb spasticity and weakness. To date, more than 80 genetic HSP types have been identified.
Woong‐Woo Lee, Cha Gon Lee, Chang‐Seok Ki   +2 more
wiley   +1 more source

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

PLoS Computational Biology, 2015
G protein-gated K+ channels (GIRK; Kir3), activated by Gβγ subunits derived from Gi/o proteins, regulate heartbeat and neuronal excitability and plasticity.
Daniel Yakubovich, Shai Berlin, Uri Kahanovitch, Moran Rubinstein, Isabella Farhy-Tselnicker, Boaz Styr, Tal Keren-Raifman, Carmen W Dessauer, Nathan Dascal   +8 more
doaj   +1 more source