Results 91 to 100 of about 7,018 (220)

Potassium channel Kir4.1 macromolecular complex in retinal glial cells

Glia, 2005
AbstractA major role for Müller cells in the retina is to buffer changes in the extracellular K+ concentration ([K+]o) resulting from light‐evoked neuronal activity. The primary K+ conductance in Müller cells is the inwardly rectifying K+ channel Kir4.1.
Nathan C, Connors, Paulo, Kofuji
openaire   +2 more sources

Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis [PDF]

New England Journal of Medicine, 2016
An enzyme-linked immunosorbent assay of antibodies in the serum of 86 patients with multiple sclerosis and that of 51 healthy controls that used KIR4.1 as the target protein showed no significant between-group difference.
Anne, Chastre, David A, Hafler, Kevin C, O'Connor   +2 more
openaire   +2 more sources

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in pendred syndrome/enlarged vestibular aqueducts [PDF]

, 2013
Pendred syndrome is a common autosomal recessive disorder causing deafness. Features include sensorineural hearing impairment, goitre, enlarged vestibular aqueducts (EVA) and occasionally Mondini dysplasia.
Bitner-Glindzicz, M, Differ, AM, Jenkins, L, Landa, P, Rajput, K   +4 more
core   +2 more sources

Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases

International Journal of Molecular Sciences, 2021
Inwardly rectifying Kir4.1 channels in astrocytes mediate spatial potassium (K+) buffering, a clearance mechanism for excessive extracellular K+, in tripartite synapses.
Y. Ohno, Naofumi Kunisawa, S. Shimizu
semanticscholar   +1 more source

Increased KIR4.1 immunoreactivity in human glioma tissue

, 2015
66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Schirmer, L, Ringel, F, Butenschön, VM, Srivastava, R, Hemmer, B, Gempt, J   +5 more
openaire   +2 more sources

EAST syndrome: Clinical, pathophysiological, and genetic aspects of mutations in KCNJ10 [PDF]

, 2016
EAST syndrome is a recently described autosomal recessive disorder secondary to mutations in KCNJ10 (Kir4.1), a gene encoding a potassium channel expressed in the brain, eye, ear and kidney.
Abdelhadi, O, Bockenhauer, D, Iancu, D, Kleta, R, Stanescu, H   +4 more
core   +1 more source

EAST/SeSAME syndrome mutations partially disrupt trafficking of homomeric Kir4.1 channels and produce non‐functional heteromeric Kir2.3/Kir4.1 channels

The FASEB Journal, 2012
Mutations in Kir4.1 cause renal salt and Mg wasting (EAST/ SeSAME syndrome, E/S) within the DCT. We have recently found that WT Kir4.1 co‐assembles and co‐localizes with Kir2.3 to produce heteromeric channels with properties similar to native channels in distal nephron. We previously reported that E/S Kir4.1 mutants disrupt Kir2.3 function, raising the
Bernardo Ortega, Dimin Li, Bo-Young Kim, James B Wade, Paul A Welling   +4 more
openaire   +1 more source

Aquaporin-4 and brain edema. [PDF]

, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler, Alan S. Verkman, AS Verkman, AS Verkman, D Wenzel, DK Binder, DK Binder, DK Binder, DS Prough, GT Manley, H Wen, HJ Reulen, HK Kimelberg, I Klatzo, I Roberts, J Badaut, J Hu, J Li, J Li, JE Rash, JE Rash, K Oshio, KI Auguste, M Amiry-Moghaddam, M Amiry-Moghaddam, M Elkjaer, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, NR Saunders, O Bloch, P Agre, P Padmawar, PM Rodier, S Nielsen, S Saadoun, S Saadoun, T Ma   +38 more
core   +2 more sources