Results 101 to 110 of about 7,018 (220)
The Impact of Aquaporin‐4 Deletion on K+‐Induced Astrocytic Swelling Depends on K+ Concentration
Glia, Volume 74, Issue 1, January 2026.Swelling due to 10 mM [K+]o is reduced in astrocytes devoid of aquaporin‐4, while there is no difference between genotypes when exposed to 50 mM [K+]o. The two [K+]o concentrations induce distinct astrocytic Ca2+ signaling in the two genotypes pointing to a possible mechanistic basis of the differences observed. ABSTRACT Astrocytes swell in response to
Cecilie Bugge Bakketun +5 more
wiley +1 more source
Hypersensitivity Responses in the Central Nervous System [PDF]
, 2015 Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg +5 more
core +4 more sources
Glia, Volume 74, Issue 1, January 2026.Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz +6 more
wiley +1 more source
Caveolin-1 regulates corneal wound healing by modulating Kir4.1 activity [PDF]
American Journal of Physiology-Cell Physiology, 2016 The expression of caveolin-1 (Cav1) in corneal epithelium is associated with regeneration potency. We used Cav1−/− mice to study the role of Cav1 in modulating corneal wound healing. Western blot and whole cell patch clamp were employed to study the effect of Cav1 deletion on Kir4.1 current density in corneas.
Chengbiao, Zhang +3 more
openaire +2 more sources
, 2019 Deciphering the complex interactions between neurotransmission and astrocytic $Ca^{2+}$ elevations is a target promising a comprehensive understanding of brain function.
Ivanov, Vladimir A. +2 more
core +1 more source
CO2-dependent opening of an inwardly rectifying K+ channel [PDF]
, 2011 CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Dale, Nicholas, Huckstepp, Robert T. R.
core +2 more sources
Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.We established a robust predictive model for nasopharyngeal carcinoma (NPC) distant metastasis using RNA markers. When combined with clinical parameters, our RNA‐based risk score significantly improved the area under the curve to 90.4%. This study revealed that tertiary lymphoid structure formation may be associated with lower NPC metastasis risk after
Zhaozheng Hou +16 more
wiley +1 more source
Molecular Mechanisms of EAST/SeSAME Syndrome Mutations in Kir4.1 (KCNJ10) [PDF]
Journal of Biological Chemistry, 2010 Inwardly rectifying potassium channel Kir4.1 is critical for glial function, control of neuronal excitability, and systemic K(+) homeostasis. Novel mutations in Kir4.1 have been associated with EAST/SeSAME syndrome, characterized by mental retardation, ataxia, seizures, hearing loss, and renal salt waste.
Monica, Sala-Rabanal +4 more
openaire +2 more sources
Founder mutation in KCNJ10 in Pakistani patients with EAST syndrome. [PDF]
, 2016 BACKGROUND: EAST syndrome is an autosomal recessive disorder caused by loss-of-function mutations in the gene KCNJ10. Among the 14 pathogenic mutations described so far, the p.R65P mutation stands out as the most frequent one and is particularly ...
Abdelhadi, O +5 more
core +1 more source
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes
Investigative Opthalmology & Visual Science, 2020 Diabetic retinopathy (DR) is a leading cause of visual impairment. Müller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1. Metformin, a commonly used oral antidiabetic drug, is known to elicit its action through 5' adenosine monophosphate-activated protein kinase (AMPK), a cellular metabolic ...
Alex, Alpha +4 more
openaire +2 more sources