Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease [PDF]
, 2014 Background In the recent years, a role of the immune system in Huntington’s disease (HD) is increasingly recognized. Here we investigate the presence of T cell activating auto-antibodies against angiotensin II type 1 receptors (AT1R) in all stages of the
Dechend, Ralf +15 more
core +3 more sources
Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders [PDF]
, 2013 Recent studies have implicated potentially significant roles for astrocytes in the pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation process following early differentiation from which typical morphology and important ...
Haruki Higashimori +2 more
core +1 more source
Constraints of FL Motif on the Targeting and Function of Sodium-Bicarbonate Cotransporter 1 [PDF]
, 2008 A C-terminal dihydrophobic FL motif plays a vital role in the basolateral targeting of sodium bicarbonate cotransporter 1. To further characterize the role of dihydrophobic FL motif, 1). the FL motif in wild type (PFLS) was reversed to LF (PLFS), 2). the
Ali Shawki +7 more
core +1 more source
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models [PDF]
, 2013 The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K+ through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane.
Chabbert, Christian +7 more
core +1 more source
Lateral habenula dysfunction in depression: Mechanisms and therapeutic prospects [PDF]
SHS Web of ConferencesEmerging evidence implicates lateral habenula (LHb) hyperactivity—as it persistently inhibits midbrain dopamine and serotonin systems—in major depressive disorder (MDD).
Zuo Binyu
doaj +1 more source
Idiopathic epilepsy of childhood and potassium ion channels [PDF]
, 2007 Potassium can affect the development of common seizure type and can be defined seizure susceptibility allele. The existence of inward-rectifying potassium (Kir) channels was first recognized half a century ago. The biophysical fingerprint of Kir channels
Dai, Alper I, Wasay, Mohammad
core +1 more source
Caractérisation des canaux potassiques du tubule contourné proximal et des propriétés régulatrices des canaux chlorure de la membrane basolatérale des cellules intercalaires du tubule connecteur [PDF]
, 2015 A 10 pS chloride channel at the basolateral side of connecting duct intercalated cells shares properties with the cloned ClC-K2 channel. Patch-clamp experiments show that its activity and the number of active channels increase with (i) membrane ...
Pinelli, Laurent
core +2 more sources
Detection of potassium channel KIR4.1 antibodies in Multiple Sclerosis patients
Journal of Immunological Methods, 2017 The presence of KIR4.1 antibodies has been proposed to be a characteristic of Multiple Sclerosis (MS). This could have a significant impact on disease management. However, the validation of the initial findings has failed till date. Conflicting results have been attributed to difficulties in isolating the lower-glycosylated (LG) KIR4.1 expressed in ...
Marnetto F. +3 more
openaire +3 more sources
Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling
Cell Reports, 2018 Summary: Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure.
Turgay Saritas +5 more
doaj +1 more source
Contribution of Kir4.1 to the mouse electroretinogram.
Molecular vision, 2004 The electroretinogram (ERG) represents the combination of several distinct cellular processes and conductances. Here, we define the contribution that K+ conductance through Kir4.1 channels makes to the mouse ERG.To obtain mice expressing different levels of Kir4.1, we mated Kir4.1+/- mice and used PCR to identify Kir4.1+/- and Kir4.1+/+ littermates. In
Jiang, Wu +3 more
openaire +1 more source