Results 11 to 20 of about 7,018 (220)
Advanced ScienceMajor depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required. Targeted inhibition of the astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1) in the lateral habenula could rapidly ...
Sisi Wang +15 more
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Cells, 2023 A single sub-anesthetic dose of ketamine evokes rapid and long-lasting beneficial effects in patients with a major depressive disorder. However, the mechanisms underlying this effect are unknown.
Mićo Božić +6 more
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Nature CommunicationsFragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss of the mRNA-binding fragile X mental retardation protein (FMRP). FXS is characterized by neuronal hyperexcitability and behavioral defects, however the mechanisms
Danijela Bataveljic +9 more
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JCI Insight, 2023 We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 in the distal convoluted tubule (DCT). Application of tacrolimus (FK506) or cyclosporine A (CsA) increased whole-
Dan-Dan Zhang +7 more
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Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
Communications BiologyAstrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+.
Colin M. Cleary +10 more
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Kir4.1 Dysfunction in the Pathophysiology of Depression: A Systematic Review [PDF]
Cells, 2021 A serotonergic dysfunction has been largely postulated as the main cause of depression, mainly due to its effective response to drugs that increase the serotonergic tone, still currently the first therapeutic line in this mood disorder.
Stefania Della Vecchia +3 more
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Kir4.1 Regulates The Orofacial Pain After Trigeminal Nerve Injury
International Dental JournalAim or purpose: Kir4.1 emerged as a novel therapeutic target for nervous system diseases, such as depression. However, the role and mechanism of Kir4.1 in peripheral and central sensitization after trigeminal neuropathic pain is still unclear.
Jiu Lin, Chen Qianming
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Kir4.1 and Aqp4 Contribution to Schisis Cystic Water Accumulation and Clearance in the Rs1 Exon-1 Del XLRS Rat Model. [PDF]
Genes (Basel)Background/Objective: The Rs1 exon-1-del rat (Rs1KO) XLRS model shows normal retinal development until postnatal day 12 (P12) when small cystic spaces start to form in the inner nuclear layer.
Smit-McBride Z +5 more
europepmc +2 more sources
The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]
PLoS Computational Biology, 2015 Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille +3 more
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Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity [PDF]
eLife, 2018 Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressive ...
Lucas Schirmer +20 more
doaj +7 more sources