Results 191 to 200 of about 7,018 (220)

KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential

American Journal of Physiology-Cell Physiology, 2002
Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions
Daniel C, Marcus, Tao, Wu, Philine, Wangemann, Paulo, Kofuji   +3 more
openaire   +2 more sources

The Impact of Astroglia Kir4.1 Channel Dysfunction on Neuronal Activity and Autism‐Related Behavioral Abnormalities

Glia
Autism spectrum disorder (ASD) is marked by neurobehavioral developmental deficits, potentially linked to disrupted neuron–glia interactions. The astroglia Kir4.1 channel plays a vital role in regulating potassium levels during neuronal activation, and ...
Shima Davoudi, M. Rahdar, Mehdi Borjkhani, Hamid Alavi-Majd, N. Hosseinmardi, G. Behzadi, M. Janahmadi   +6 more
semanticscholar   +1 more source

Activation of Kir4.1/Kir5.1 contributes to the cyclosporin A‐induced stimulation of the renal NaCl cotransporter and hyperkalemic hypertension

Acta Physiologica, 2023
Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide‐sensitive NaCl cotransporter (NCC) in the kidney has been shown to be responsible for the development
Zhong-Xiuzi Gao, R. Zhou, Mingyan Li, Shu-Ting Li, Z. Mao, T.T. Shu, Dong Liu, Zhang-Suo Liu, Peng Wu   +8 more
semanticscholar   +1 more source

Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions

Annals of Neurology, 2014
ObjectiveSerum antibodies against the glial potassium channel KIR4.1 are found in a subpopulation of multiple sclerosis (MS) patients. Little is known about the expression of KIR4.1 in human normal brain tissue and in MS lesions.MethodsWe analyzed the expression pattern of KIR4.1 in normal brain tissue and MS lesions of the subcortical white matter by ...
Lucas, Schirmer, Rajneesh, Srivastava, Sudhakar Reddy, Kalluri, Susanne, Böttinger, Marina, Herwerth, Daniele, Carassiti, Barkha, Srivastava, Jens, Gempt, Jürgen, Schlegel, Tanja, Kuhlmann, Thomas, Korn, Richard, Reynolds, Bernhard, Hemmer   +12 more
openaire   +2 more sources

Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter.

AJP - Renal Physiology
Angiotensin-II (Ang-II) perfusion stimulates Kir4.1/Kir5.1 in distal-convoluted-tubule (DCT) and thiazide sensitive Na-Cl-cotransporter (NCC). The aim of the present study is to explore the role of Kir4.1/Kir5.1 in mediating the effect of Ang-II on NCC ...
Xin-Peng Duan, Xinxin Meng, Yu Xiao, Cheng-Biao Zhang, R. Gu, Daohong Lin, Wen-Hui Wang   +6 more
semanticscholar   +1 more source

Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na+ Channel (ENaC)

HYPERTENSION, 2023
BACKGROUND: Kir4.2 and Kir4.1 play a role in regulating membrane transport in the proximal tubule (PT) and in the distal-convoluted-tubule (DCT), respectively.
Xin-Peng Duan, Yu Xiao, X. Su, Jun-Ya Zheng, Susan B Gurley, Jacqueline M. Emathinger, Chao‐ling Yang, James A. McCormick, David H. Ellison, Daohong Lin, Wen‐Hui Wang   +10 more
semanticscholar   +1 more source

[The function and regulation of basolateral Kir4.1 and Kir4.1/Kir5.1 in renal tubules].

Sheng li xue bao : [Acta physiologica Sinica], 2019
Basolateral inwardly-rectifying K+ channels (Kir) play an important role in the control of resting membrane potential and transepithelial voltage, thereby modulating water and electrolyte transport in the distal part of nephron. Kir4.1 and Kir4.1/Kir5.1 heterotetramer are abundantly expressed in the basolateral membrane of late thick ascending limb ...
Yu, Xiao, Xin-Xin, Meng, Hao, Zhang, Xi-Wen, Guo, Rui-Min, Gu   +4 more
openaire   +1 more source

Kir4.1 deletion prevents salt-sensitive hypertension in early streptozotocin-induced diabetic mice via Na+–Cl− cotransporter in the distal convoluted tubule

Journal of Hypertension, 2023
Objectives: Functional impairment of renal sodium handling and blood pressure (BP) homeostasis is an early characteristic manifestation of type 1 diabetes. However, the underlying mechanisms remain unclear.
Zhong-Xiuzi Gao, Qi-Chao Wei, T.T. Shu, Shu-Ting Li, R. Zhou, Ming-Yan Li, Z. Mao, Dong Liu, Zhang-Suo Liu, Peng Wu   +9 more
semanticscholar   +1 more source

High potassium enhances the immunosuppressive function of myeloid-derived suppressor cells via Kir4.1-dependent metabolic reprogramming and promotes tumor immune escape.

International Journal of Cancer
Despite advances in cancer immunotherapy, low response rates remain a critical clinical challenge. Myeloid-derived suppressor cells (MDSCs) drive tumor immune evasion by directly suppressing antitumor immunity, positioning them as prime therapeutic ...
Zhiqi Xie, Jiayi Liu, Ying Chen, Kexin Wang, Ziyi Hong, Yanjie Li, Luqiong Liang, Jinglu Bi, Yuanzhen Jin, Weida Shen, Masashi Tachibana, Zeren Shen, Jinjin Shao   +12 more
semanticscholar   +1 more source

Astrocytic Kir4.1 ion channel deficit drives persistent inflammatory facial pain in males.

Brain : a journal of neurology
Chronic facial pain, a frequent and disabling condition, is maintained by central sensitization, which results in pain hypersensitivity. Although it is well established that reactive astrocytes play a key role in persistent pain mechanisms, the role of ...
Sarah Mountadem, Karine Herault, Cedric Peirs, Gisela da Silva Borges, D. Voisin, Myriam Antri, Radhouane Dallel   +6 more
semanticscholar   +1 more source