Results 21 to 30 of about 7,018 (220)

Potassium Channel Subunit Kir4.1 Mutated in Paroxysmal Kinesigenic Dyskinesia: Screening of an Italian Cohort. [PDF]

Mov Disord
The missing heritability of paroxysmal kinesigenic dyskinesia (PKD) may be explained by genetic heterogeneity with unexplored contributions of genes other than PRRT2 or TMEM151A .
Zorzi G, Zibordi F, Sorrentino U, Prokisch H, Garavaglia B, Zech M.   +5 more
europepmc   +2 more sources

Role of Kir4.1 Channel in Auditory Function: Impact on Endocochlear Potential and Hearing Loss

Applied Sciences
Hearing loss can result from impairments in structures that support endocochlear potential, as they play a crucial role in the transduction and transmission of auditory waves. This aspect has been the subject of several studies to date.
Silvia Fracaro, Filippo Hellies, Gino Marioni, Davide Brotto, Sebastiano Franchella, Elisabetta Zanoletti, Giovanna Albertin, Laura Astolfi   +7 more
doaj   +2 more sources

Polyamine permeation and rectification of kir4.1 channels [PDF]

Channels, 2007
Inward rectifier K(+) (Kir) channels are expressed in multiple neuronal and glial cells. Recent studies have equated certain properties of exogenously expressed Kir4.1 channels with those of native K(+) currents in brain cells, as well as demonstrating the expression of Kir4.1 subunits in these tissues. There are nagging problems however with assigning
Eaton, Misty J, Kucheryavykh, Yuri V, Kurata, Harley T, Nichols, Colin G, Pearson, Wade L, Skatchkov, Serguei N   +5 more
core   +5 more sources

Kir4.1-mediated immunophenotypic OPCs underlies sevoflurane-induced hypomyelination in the developing brain

Brain Research Bulletin
Clinical and animal experimental studies demonstrate that prolonged or repeated general anesthesia (GA) impairs myelination in the developing brain. However, the underlying cellular mechanisms remain unclear.
Liping Sun, Luping Feng, Yuxin Zhang, Mengqin Shan, Chaoyang Tong, Kan Zhang, Jijian Zheng, Xin Fu   +7 more
doaj   +2 more sources

Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels. [PDF]

J Biol Chem
Lee SJ, Gao J, Thompson E, Mount J, Nichols CG.   +4 more
europepmc   +2 more sources

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion. [PDF]

Adv Sci (Weinh)
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ahlgreen OA, Hansen MW, Baake J, Hybel TE, Rossi R, Lai X, Sankaranarayanan I, Pold JA, Lin L, Reinert L, Paludan SR, Price TJ, Pallesen LT, Vægter CB.   +13 more
europepmc   +2 more sources

Absence of antibodies against KIR4.1 in multiple sclerosis: A three-technique approach and systematic review. [PDF]

PLoS ONE, 2017
Antibodies targeting the inward-rectifying potassium channel KIR4.1 have been associated with multiple sclerosis (MS) but studies using diverse techniques have failed to replicate this association. The detection of these antibodies is challenging; KIR4.1
Miquel Navas-Madroñal, Ana Valero-Mut, María José Martínez-Zapata, Manuel Javier Simón-Talero, Sebastián Figueroa, Nuria Vidal-Fernández, Mariana López-Góngora, Antonio Escartín, Luis Querol   +8 more
doaj   +1 more source

Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship? [PDF]

CNS Neurosci Ther
Circadian rhythm is offering novel insights into the pathogenesis of retinopathy. Bmal1, a key transcriptional regulator of the circadian clock, serves as a critical pathologic cofactor in retinal degeneration. Deficiency in Bmal1 contributes to a broad spectrum of retinal pathological alterations, and modulating the clock gene Bmal1 could potentially ...
Cui Y, Li H, Fan W, Wu H, Wang J, Qu C, Pu N, Tao Y.   +7 more
europepmc   +2 more sources

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage. [PDF]

Glia
Main Points NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nboe1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in ...
Capuk O, Berthold E, Kaliyappan K, Avunoori M, Muduganti R, Krishna S, Metwally S, McFarland M, Song S, Fiesler V, Fischer S, Foley LM, Hitchens TK, Waxman S, Sigal IA, Theparambil SM, Begum G.   +16 more
europepmc   +2 more sources

Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009
This work demonstrates that extracellular Na(+) modulates the cloned inwardly rectifying K(+) channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external Na(+). We expressed Kir4.1 and Kir4.1-Kir5.1 in Xenopus oocytes to disclose if Kir4.1 and/or Kir4.
Søe, Rikke, Andreasen, Mogens, Klærke, Dan Arne   +2 more
openaire   +7 more sources