Results 31 to 40 of about 7,018 (220)

KIR4.1 Antibodies as Biomarkers in Multiple Sclerosis [PDF]

Frontiers in Neurology, 2014
Multiple sclerosis (MS) is an autoimmune disease caused by the infiltration of autoreactive lymphocytes into the central nervous system (CNS). The influence of B cells has been underestimated for a long time. Recently, it has become more apparent that B cells can fundamentally contribute to the pathogenesis of MS in terms of antigen presentation, co ...
Wunsch, Marie, Rovituso, Damiano M., Kuerten, Stefanie   +2 more
openaire   +3 more sources

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. [PDF]

PLoS ONE, 2018
Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels.
Kayla Thompson, Jonathan Chen, Qianyi Luo, Yucheng Xiao, Theodore R Cummins, Ashay D Bhatwadekar   +5 more
doaj   +1 more source

Inhibition of Kir4.1 potassium channels by quinacrine [PDF]

Brain Research, 2017
Inwardly rectifying potassium (Kir) channels are expressed in many cell types and contribute to a wide range of physiological processes. Particularly, Kir4.1 channels are involved in the astroglial spatial potassium buffering. In this work, we examined the effects of the cationic amphiphilic drug quinacrine on Kir4.1 channels heterologously expressed ...
Leticia G, Marmolejo-Murillo, Iván A, Aréchiga-Figueroa, Meng, Cui, Eloy G, Moreno-Galindo, Ricardo A, Navarro-Polanco, José A, Sánchez-Chapula, Tania, Ferrer, Aldo A, Rodríguez-Menchaca   +7 more
openaire   +2 more sources

Anti-Kir4.1 Antibodies in Multiple Sclerosis: Specificity and Pathogenicity [PDF]

International Journal of Molecular Sciences, 2020
The glial cells in the central nervous system express diverse inward rectifying potassium channels (Kir). They express multiple Kir channel subtypes that are likely to have distinct functional roles related to their differences in conductance, and sensitivity to intracellular and extracellular factors. Dysfunction in a major astrocyte potassium channel,
Michie Imamura, Osamu Higuchi, Yasuhiro Maeda, Akihiro Mukaino, Mitsuharu Ueda, Hidenori Matsuo, Shunya Nakane   +6 more
openaire   +2 more sources

The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet

Frontiers in Physiology, 2022
Basolateral potassium channels in the distal convoluted tubule (DCT) are composed of inwardly-rectifying potassium channel 4.1 (Kir4.1) and Kir5.1. Kir4.1 interacts with Kir5.1 to form a 40 pS K+ channel which is the only type K+ channel expressed in the
Xin-Xin Meng, Hao Zhang, Gui-Lin Meng, Shao-Peng Jiang, Xin-Peng Duan, Wen-Hui Wang, Ming-Xiao Wang   +6 more
doaj   +1 more source

Potassium Sensing by Renal Distal Tubules Requires Kir4.1 [PDF]

Journal of the American Society of Nephrology, 2017
The mammalian distal convoluted tubule (DCT) makes an important contribution to potassium homeostasis by modulating NaCl transport. The thiazide-sensitive Na+/Cl− cotransporter (NCC) is activated by low potassium intake and by hypokalemia. Coupled with suppression of aldosterone secretion, activation of NCC helps to retain potassium by increasing ...
Catherina A, Cuevas, Xiao-Tong, Su, Ming-Xiao, Wang, Andrew S, Terker, Dao-Hong, Lin, James A, McCormick, Chao-Ling, Yang, David H, Ellison, Wen-Hui, Wang   +8 more
openaire   +2 more sources

Disentangling astroglial physiology with a realistic cell model in silico [PDF]

, 2018
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry.
A Araque, A Chvatal, A Grosche, A Panatier, A Verkhratsky, A Volterra, A Wallraff, AM Reeves, B Djukic, BA MacVicar, BS Khakh, C Giaume, C Henneberger, CC Fink, DA Rusakov, DA Rusakov, DA Rusakov, DE Bergles, E Scemes, E Shigetomi, EA Bushong, EA Newman, F Ding, F Oschmann, G Seifert, G Ullah, G Wallach, GG Viola, I Patrushev, J Golowasch, J Grosche, J Schaff, J Sibille, K Hama, K Ogata, K Thurley, K Zheng, K Zheng, KC Chen, KP Lehre, KP Lehre, KY Zheng, LP Savtchenko, LP Savtchenko, M Nedergaard, M Pitta De, M Pitta De, MA Castro Di, MD Haustein, MJ Berridge, ML Hines, ML Hines, MR Witcher, N Bazargani, N Hernjak, N Medvedev, P Kofuji, PX Cao, R Srinivasan, R Ventura, RL Rungta, S Anders, S Sylantyev, T Hofer, T Manninen, TaufiqUrRahman, TW Chen, V Parpura, WN Ross, Z Wang, Z Zhang   +70 more
core   +3 more sources

Functional interaction between aquaporins and Kir4.1/Kir4.1‐Kir5.1 channels

The FASEB Journal, 2007
In the CNS glial cells, Kir4.1 and Kir4.1‐Kir5.1 channels are involved in clearance of K + during neuronal activity. A number of studies have shown that Kir channels are co‐localized with aquaporins (AQP4) in the glial cells, and coupled water and K ...
Rikke Søe, Dan Arne Klærke
openaire   +1 more source

Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis

Frontiers in Neurology, 2020
Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability.
Masato Kinboshi, Masato Kinboshi, Akio Ikeda, Yukihiro Ohno   +3 more
doaj   +1 more source

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source