Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux +68 more
core +2 more sources
Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region
Frontiers in Pharmacology, 2018 Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering.
Takahiro Mukai +12 more
doaj +1 more source
Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination [PDF]
, 2001 To understand the cellular and in vivo functions of specific K^+ channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K^+ channel subunit Kir4.1.
Jacobs, Russell E. +4 more
core +1 more source
Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]
, 2015 Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
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Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]
, 2015 BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád +3 more
core +1 more source
The central role of aquaporins in the pathophysiology of ischemic stroke [PDF]
, 2015 Stroke is a complex and devastating neurological condition with limited treatment options. Brain edema is a serious complication of stroke. Early edema formation can significantly contribute to infarct formation and thus represents a promising target ...
Di Giovanni, Giuseppe +4 more
core +6 more sources
Brain Sciences, 2020 Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% of diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured
Miguel P. Méndez-González +6 more
doaj +1 more source
Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
core +1 more source
The FASEB Journal, 2011 The Kir4.1 channel is expressed in the brainstem, retina and kidney. Its heteromerization with Kir5.1 leads to K + currents with distinct properties such as single‐channel conductance, rectification, pH sensitivity and phosphorylation modulations.
Xin Jin +4 more
openaire +1 more source
Kir4.1 K+channels are regulated by external cations [PDF]
Channels, 2011 The inwardly rectifying potassium channel (Kir), Kir4.1 mediates spatial K(+)-buffering in the CNS. In this process the channel is potentially exposed to a large range of extracellular K(+) concentrations ([K(+)]o). We found that Kir4.1 is regulated by K(+)o.
Johan M, Edvinsson +2 more
openaire +2 more sources