Results 61 to 70 of about 7,018 (220)
EBioMedicine, 2023 Summary: Background: Stroke is one of the most common neurological diseases in the world and is clinically manifested by transient or permanent brain dysfunction.
Xiaoqi Hong +9 more
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Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome [PDF]
, 2015 Rett syndrome is a prototypical neurological disorder characterised by abnormal breathing pattern and reduced ventilatory CO2 sensitivity. Medullary astrocytes are a crucial component of central CO2 /pH chemosensitivity.
Abdala, AP +3 more
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KIR4.1: K+ channel Illusion or Reality in the autoimmune pathogenesis of multiple sclerosis
Frontiers in Molecular Neuroscience, 2016 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Many believe autoimmune pathogenesis plays a key role in MS, but its target(s) remains elusive.
Chen Gu
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Role of Kir4.1 channels in growth control of glia [PDF]
Glia, 2007 AbstractThe inwardly rectifying potassium channel Kir4.1 is widely expressed by astrocytes throughout the brain. Kir4.1 channels are absent in immature, proliferating glial cells. The progressive expression of Kir4.1 correlates with astrocyte differentiation and is characterized by the establishment of a negative membrane potential (> −70 mV) and an
Haruki, Higashimori, Harald, Sontheimer
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Frontiers in Genetics, 2019 Inwardly rectifying K+ channel 4.1 (Kir4.1), encoded by KCNJ10, is a member of the inwardly rectifying potassium channel family. In the brain, Kir4.1 is predominant in astrocytic glia and accounts for the spatial buffering of K+ released by neurons ...
Hongfeng Zhang +14 more
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Frontiers in Physiology, 2023 The inward-rectifying potassium channel subunit Kir5.1, encoded by Kcnj16, can form functional heteromeric channels (Kir4.1/5.1 and Kir4.2/5.1) with Kir4.1 (encoded by Kcnj10) or Kir4.2 (encoded by Kcnj15).
Chaojie Zhang +7 more
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Human Genomics, 2019 Background Dysfunction in inwardly rectifying potassium channel Kir4.1 has been implicated in SeSAME syndrome, an autosomal-recessive (AR), rare, multi-systemic disorder.
Ravi K. Nadella +15 more
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Effects of aquaporin 4 and inward rectifier potassium channel 4.1 on medullospinal edema after methylprednisolone treatment to suppress acute spinal cord injury in rats [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To investigate the effects of aquaporin 4 (AQP4) and inward rectifier potassium channel 4.1 (Kir4.1) on medullospinal edema after treatment with methylprednisolone (MP) to suppress acute spinal cord injury (ASCI) in rats.
Ye Li +4 more
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Dystroglycan and Kir4.1 coclustering in retinal Müller glia is regulated by laminin‐1 and requires the PDZ‐ligand domain of Kir4.1 [PDF]
Journal of Neurochemistry, 2005 AbstractInwardly rectifying potassium (Kir) channels in Müller glia play a critical role in the spatial buffering of potassium ions that accumulate during retinal activity. To this end, Kir channels show a polarized subcellular distribution with the predominant channel subunit in Müller glia, Kir4.1, clustered in the endfeet of these cells at the inner
Geoffrey, Noël +5 more
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The Journal of Clinical Investigation, 2023 Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Hannah Kapell +41 more
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