Results 81 to 90 of about 7,018 (220)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Fast ripple‐delta coupling as an early biomarker for post‐traumatic epileptogenesis in repetitive brain injury

Epilepsia Open, EarlyView.
Abstract Objective Traumatic brain injury (TBI) can induce posttraumatic epilepsy (PTE), but early biomarkers for epileptogenesis are lacking. We aimed to investigate electrographic biomarkers before and during posttraumatic seizure development. Methods We used a repetitive diffuse TBI model in mice with continuous video‐EEG monitoring up to 4½ months ...
Oleksii Shandra, Dzenis Mahmutovic, Biswajit Maharathi, Md Adil Arman, Michael J. Benko, Owen Leitzel, Pritom Kumar Saha, Stefanie Robel   +7 more
wiley   +1 more source

Variable loss of Kir4.1 channel function in SeSAME syndrome mutations [PDF]

Biochemical and Biophysical Research Communications, 2010
SeSAME syndrome is a complex disease characterized by seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance. Mutations in the inwardly rectifying potassium channel Kir4.1 (KCNJ10 gene) have been linked to this condition. Kir4.1 channels are weakly rectifying channels expressed in glia, kidney, cochlea and possibly other
Xiaofang, Tang, Darwin, Hang, Andrea, Sand, Paulo, Kofuji   +3 more
openaire   +2 more sources

Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury.

Brain : a journal of neurology
Spasticity, a prevalent motor issue characterized by network hyperexcitability, causes pain and discomfort, with existing treatments offering limited relief.
Tony Barbay, Emilie Pecchi, Jorge Ramirez-Franco, Anton Ivanov, F. Brocard, N. Rouach, Rémi Bos   +6 more
semanticscholar   +2 more sources

Unidirectional photoreceptor-to-Müller glia coupling and unique K+ channel expression in Caiman retina. [PDF]

PLoS ONE, 2014
Müller cells, the principal glial cells of the vertebrate retina, are fundamental for the maintenance and function of neuronal cells. In most vertebrates, including humans, Müller cells abundantly express Kir4.1 inwardly rectifying potassium channels ...
Astrid Zayas-Santiago, Silke Agte, Yomarie Rivera, Jan Benedikt, Elke Ulbricht, Anett Karl, José Dávila, Alexey Savvinov, Yuriy Kucheryavykh, Mikhail Inyushin, Luis A Cubano, Thomas Pannicke, Rüdiger W Veh, Mike Francke, Alexei Verkhratsky, Misty J Eaton, Andreas Reichenbach, Serguei N Skatchkov   +17 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies

Frontiers in Physiology, 2022
In 2009, two groups independently linked human mutations in the inwardly rectifying K+ channel Kir4.1 (gene name KCNJ10) to a syndrome affecting the central nervous system (CNS), hearing, and renal tubular salt reabsorption.
Jacky Lo, Anna-Lena Forst, Richard Warth, Anselm A. Zdebik, Anselm A. Zdebik   +4 more
doaj   +1 more source

The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy [PDF]

, 2011
Autism is a complex behavioral disorder that develops prior to age three years and is distinguished by high heritability. Many genes predisposing to autism spectrum disorders (ASDs) have been identified.
D’Adamo, Maria Cristina, Imbrici, Paola, Martino, Dianda, Moro, Francesca, Pessia, Mauro, Roscini, Mauro, Santorelli, Filippo Maria, Sicca, Federico   +7 more
core  

Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network

Glia, 2023
Neuronal rhythmogenesis in the spinal cord is correlated with variations in extracellular K+ levels ([K+]e). Astrocytes play important role in [K+]e homeostasis and compute neuronal information.
Tony Barbay, É. Pecchi, Myriam-Isabelle Ducrocq, N. Rouach, F. Brocard, Rémi Bos   +5 more
semanticscholar   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source