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GPR54 and kisspeptin in reproduction [PDF]
Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour metastasis, hence the name of ...
Manuel Tena-Sempere
exaly +4 more sources
Kisspeptin and Glucose Homeostasis [PDF]
AbstractKisspeptin has well-established critical roles in the control of reproduction and fertility. Recently, evidence has emerged that suggests kisspeptin may have additional roles in the regulation of glucose homeostasis. Conflicting reports on the effects of kisspeptin on insulin secretion in animal models have been published, which cannot be fully
Izzi-Engbeaya, Chioma +2 more
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Seminars in Reproductive Medicine, 2019
AbstractThe relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of kisspeptin has provided novel insights into how prolactin might cause infertility, with extensive evidence that elevated prolactin inhibits ...
David R. Grattan, Raphael E. Szawka
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AbstractThe relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of kisspeptin has provided novel insights into how prolactin might cause infertility, with extensive evidence that elevated prolactin inhibits ...
David R. Grattan, Raphael E. Szawka
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Kisspeptin and Seasonality of Reproduction [PDF]
Wild and domesticated species display seasonality in reproductive function, controlled predominantly by photoperiod. Seasonal alterations in breeding status are caused by changes in the secretion of gonadotropin-releasing hormone (GnRH) that are mediated by upstream neuronal afferents that regulate the GnRH cells.
Clarke, Iain J, Caraty, Alain
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Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
Brain Research, 2010Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction and is essential for the initiation of human puberty and maintenance of adult reproduction. Kisspeptin neurons appear to be integrative sensors, as they respond to changes in numerous internal and external factors including nutrient and fat status, stress and sex
Jyothis George +6 more
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2016
Kisspeptin is a neuropeptide that has been found to be essential for mammalian reproduction; this has been proven by the fact that, in rodents and humans, lack of Kiss1/KISS1 or its receptor Gpr54/GPR54 gene leads to hypogonadotropic hypogonadism. This peptidergic neuron expresses estrogen receptor α, which is also essential for mouse reproduction, and
Shinji Kanda, Yoshitaka Oka
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Kisspeptin is a neuropeptide that has been found to be essential for mammalian reproduction; this has been proven by the fact that, in rodents and humans, lack of Kiss1/KISS1 or its receptor Gpr54/GPR54 gene leads to hypogonadotropic hypogonadism. This peptidergic neuron expresses estrogen receptor α, which is also essential for mouse reproduction, and
Shinji Kanda, Yoshitaka Oka
openaire +2 more sources
2010
In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis.
Saira Hameed, Waljit S. Dhillo
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In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis.
Saira Hameed, Waljit S. Dhillo
openaire +3 more sources

