Results 81 to 90 of about 16,997 (262)
Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons
Frontiers in Endocrinology, 2016 Kisspeptin, a newly discovered neuropeptide regulates gonadotropin-releasing hormone (GnRH). Kisspeptins are a large RF-amide family of peptides. The kisspeptin coded by kiss1 gene is a 145-amino acid- protein that is cleaved to C-terminal peptide ...
Tomoko eSoga +3 more
doaj +1 more source
A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. [PDF]
, 2016 Fertility depends on the correct maturation and function of approximately 800 gonadotropin-releasing hormone (GnRH) neurons in the brain. GnRH neurons are at the apex of the hypothalamic-pituitary-gonadal axis that regulates fertility. In adulthood, GnRH
Hoffmann, Hanne M, Mellon, Pamela L
core +1 more source
Concentration–QTc Modeling to Support Clinical Development of Fezolinetant
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen +6 more
wiley +1 more source
Regulation and Possible Functions of Kisspeptin in the Medial Amygdala
Frontiers in Endocrinology, 2017 Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility.
Shannon B. Z. Stephens +1 more
doaj +1 more source
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
Naira da Silva Mansano +2 more
wiley +1 more source
Kisspeptin as a Behavioral Hormone
Seminars in Reproductive Medicine, 2019 AbstractSuccessful reproduction is dependent not only on hormonal endocrine responses but also on suitable partner selection, copulatory acts, as well as associated emotional, behavioral, and cognitive processes many of which are supported by the limbic system.
Mills, EGA, O'Byrne, KT, Comninos, AN
openaire +4 more sources
Sexual Dimorphism in Kisspeptin Signaling
Cells, 2022 Kisspeptin (KP) and kisspeptin receptor (KPR) are essential for the onset of puberty, development of gonads, and maintenance of gonadal function in both males and females. Hypothalamic KPs and KPR display a high degree of sexual dimorphism in expression and function.
Eun Bee Lee +6 more
openaire +3 more sources
Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. [PDF]
PLoS ONE, 2009 BACKGROUND:Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical for gonadotropin secretion are located in the hypothalamic arcuate (ARC)
Xiao-Feng Li +10 more
doaj +1 more source
Follicle size on day of trigger most likely to yield a mature oocyte [PDF]
, 2018 Funding: MRC, BBSRC and NIHR and supported by the NIHR/Wellcome Trust Imperial Clinical Research Facility and Imperial Biomedical Research Centre.Objective: To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following ...
Alexander N. Comninos +12 more
core +3 more sources
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract The neuroendocrine control of growth is mediated by the hypothalamic–pituitary–somatic (HPS) axis. This involves the hypothalamic release of growth hormone‐releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone (GH).
Bradley B. Jamieson
wiley +1 more source