Results 81 to 90 of about 21,456 (303)

Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes

Endocrinology, Diabetes & Metabolism, 2019
Introduction Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating ...
Henry Asare‐Anane, Emmanuel Kwaku Ofori, Genevieve Kwao‐Zigah, Richmond O. Ateko, Benjamin D. R. T. Annan, Afua B. Adjei, Michael Quansah   +6 more
doaj   +1 more source

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core   +1 more source

Morphine Attenuates Testosterone Response to Central Injection of Kisspeptin in Male Rats [PDF]

International Journal of Fertility and Sterility, 2014
Background Kisspeptin and naloxone stimulate the reproductive axis while morphine inhibits its function. We have investigated the effect of central injection of kisspeptin-10 on mean plasma testosterone concentration in morphine or naloxone pretreated
Fariba Mahmoudi, Homayoun Khazali, Mahyar Janahmadi   +2 more
doaj  

Effect of Peripheral Administration of Kisspeptin-10 on Dynamic LH Secretion in Prepubertal Ewes [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
The aim of the present study was to clarify the effect of kisspeptin-10 on LH secretion in prepubertal ewes. In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 ...
Jun Wang, Lei Sun, Tao Zhang, Haizhu Zhou, Yujie Lou   +4 more
doaj   +1 more source

Estrogen regulation of the molecular phenotype and active translatome of AVPV kisspeptin neurons.

Endocrinology, 2021
In females, ovarian estradiol (E2) exerts both negative and positive feedback regulation on the neural circuits governing reproductive hormone secretion, but the cellular and molecular mechanisms underlying this remain poorly understood.
Shannon B. Z. Stephens, A. Kauffman
semanticscholar   +1 more source

Substance P regulates puberty onset and fertility in the female mouse [PDF]

, 2015
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S., Gill, J.C., Kaiser, U.B., Maguire, C.A., Navarro, V.M., Simavli, Serap Aynur, Thompson, I.R., Wolfe, A.   +7 more
core   +1 more source

Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats

Frontiers in Physiology, 2022
The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon, Ji Young Eom, Woo Jung Lee, Han Saem Choi, Kyungchul Song, Junghwan Suh, Hyun Wook Chae, Ho-Seong Kim   +7 more
doaj   +1 more source

The "ram effect": new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions [PDF]

, 2015
Reproduction in mammals is controlled by the hypothalamo-pituitary-gonadal (HPG) axis under the influence of external and internal factors such as photoperiod, stress, nutrition, and social interactions.
Abbott, Alim, Bakker, Baldwin, Baum, Beltramino, Ben Saïd, Birch, Blache, Boehm, Brennan, Brennan, Buck, Budry, Cahill, Caraty, Caraty, Chand, Chanvallon, Chanvallon, Chanvallon, Chanvallon, Chemineau, Clarke, Clarkson, Claude Fabre-Nys, Cohen-Tannoudji, Cohen-Tannoudji, Cohen-Tannoudji, De Bond, Dobson, Dorries, Dyrmundsson, Eley, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Ferin, Fisher, Follett, Franceschini, Fulkerson, Gelez, Gelez, Gelez, Gelez, Ghenim, Gitler, Goldman, Goodman, Goodman, Goodman, Goodman, Goodman, Goodman, Goodman, Hamada, Hauger, Hawken, Hawken, Hawken, Herbison, Herbison, Herbison, Hodson, Hoffman, Hudson, Ichimaru, Jansen, Jiang, Johnson, Jorre de St. Jorre, Karsch, Karsch, Karsch, Kaynard, Keith M. Kendrick, Kelliher, Kendrick, Kevetter, Knight, Knight, Knobil, Kumar, Land, Lee, Lehman, Lindsay, Lindsay, Lévy, Maeda, Malpaux, Martin, Martin, Mauléon, Merkley, Messager, Mikkelsen, Moenter, Mori, Mormede, Murata, Murphy, Murtagh, Ohara, Ohkura, Oldham, Oldham, Oldham, Over, Pearce, Perkins, Pinilla, Poindron, Rex J. Scaramuzzi, Rivier, Roa, Sanchez-Andrade, Sara, Scaramuzzi, Shea, Shipka, Signoret, Signoret, Skinner, Swaney, Swann, Szawka, Thimonier, Tillet, Tillet, Tomaszewska-Zaremba, Tong, Tournadre, Treves, Tsutsumi, Uenoyama, Underwood, Ungerfeld, Ungerfeld, Vandenbergh, Walkden-Brown, Watson, Wersinger, Whitten, Yang, Yang, Yang, Yoon   +151 more
core   +4 more sources

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance

Reproductive Biology and Endocrinology, 2021
Background Energy balance is closely related to reproductive function, wherein hypothalamic kisspeptin mediates regulation of the energy balance. However, the central mechanism of kisspeptin in the regulation of male reproductive function under different
Bo Chang, Chenglin Song, Haining Gao, Tie Ma, Tao Li, Qian Ma, Tingting Yao, M. Wang, Jing Li, Xuejie Yi, Donghui Tang, Shi-cheng Cao   +11 more
semanticscholar   +1 more source

Concentration–QTc Modeling to Support Clinical Development of Fezolinetant

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen, Masako Saito, Xuegong Wang, Megumi Iwai, Graeme L. Fraser, Steven Ramael, Jiayin Huang   +6 more
wiley   +1 more source