Results 81 to 90 of about 16,602 (265)

Hypothalamic KiSS1/GPR54 Gene Expressions and Luteinizing Hormone Plasma Secretion in Morphine Treated Male Rats [PDF]

International Journal of Fertility and Sterility, 2018
Background: The inhibitory effects of morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release.
Homayoun Khazali, Fariba Mahmoudi, Mahyar Janahmadi   +2 more
doaj   +1 more source

Circadian regulation of reproduction: From gamete to offspring [PDF]

, 2013
P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
core   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

International Journal of Endocrinology, 2020
Objective. Kisspeptin, a puberty control neuropeptide, has been discovered to have an additional role in metabolism and glucose homeostasis regulation.
Kochakorn Sithinamsuwan, Pat Mahachoklertwattana, Somboon Wankanit, Suwannee Chanprasertyothin, Sarunyu Pongratanakul, Patcharin Khlairit, Preamrudee Poomthavorn   +6 more
doaj   +1 more source

Positive correlation of oestradiol level on trigger day with the secretion level of endometrial kisspeptin and leukaemia Inhibitory Factor in the Mid-Luteal Stimulated Cycle

Journal of Human Reproductive Sciences, 2022
Background: Kisspeptin plays a role in the oestradiol negative-feedback regulation of GnRH as well as gonadotropin. In addition, kisspeptin has been postulated to induce the production of an important cytokine called leukaemia inhibitory factor (LIF ...
Arie Adrianus Polim, Nusratuddin Abdullah, Mochammad Hatta, Rosdiana Natzir, Soegiharto Soebijanto, Caroline Hutomo, Aryando Pradana, Reino Rambei   +7 more
doaj   +1 more source

Intra-Testicular Signals Regulate Germ Cell Progression and Production of Qualitatively Mature Spermatozoa in Vertebrates [PDF]

, 2014
Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, FSH and LH, in response to stimulation exerted by Gonadotropin Releasing Hormone (
Gilda Cobellis, Riccardo Pierantoni, Rosanna Chianese, Rosaria Meccariello, Silvia Fasano, Teresa Chioccarelli, Vincenza Ciaramella   +6 more
core   +2 more sources

Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. [PDF]

PLoS ONE, 2009
BACKGROUND:Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical for gonadotropin secretion are located in the hypothalamic arcuate (ARC)
Xiao-Feng Li, James S Kinsey-Jones, Yewsong Cheng, Alice M I Knox, Yuanshao Lin, Nikoletta A Petrou, Antonia Roseweir, Stafford L Lightman, Stuart R Milligan, Robert P Millar, Kevin T O'Byrne   +10 more
doaj   +1 more source

Kisspeptin and Clinical Disorders [PDF]

, 2013
The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Stephanie B. Seminara, Leticia Ferreira Gontijo Silveira, Ana Claudia Latronico   +2 more
openaire   +3 more sources

Pharmacokinetics and Safety of Fezolinetant in Women with Hepatic or Renal Impairment

The Journal of Clinical Pharmacology, Volume 65, Issue 11, Page 1517-1530, November 2025.
Abstract The neurokinin 3 receptor antagonist fezolinetant is an approved treatment for vasomotor symptoms due to menopause. The impacts of hepatic and renal impairment on the pharmacokinetics and safety of a single oral dose of fezolinetant 30 mg were investigated in two independent studies.
Megumi Iwai, Xuegong Wang, Melanie Patton, Lauren Benner, Nakyo Heo, Jace C. Nielsen, Anna Spence, Thomas C. Marbury, Jiayin Huang   +8 more
wiley   +1 more source

Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons. [PDF]

PLoS ONE, 2013
Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations.
Shinji Kanda, Yasuhisa Akazome, Yuta Mitani, Kataaki Okubo, Yoshitaka Oka   +4 more
doaj   +1 more source