Results 31 to 40 of about 204,320 (304)

The Presence of gram-negative bacteria carrying the New Delhi metallo-β-lactamase gene on abiotic touch surfaces at a tertiary care center

Biomedical Research Journal, 2020
Objectives: New Delhi metallo-β-lactamase (NDM), which has emerged as a major mechanism of resistance to carbapenems in Gram-negative bacteria (GNB), challenges effective patient management of health-care systems.
Archana Agrawal, Chakrakodi N Varun, Anjali Shette, Daisy Vanitha John, Ravikumar Raju   +4 more
doaj   +1 more source

Molecular mechanismis underlying antibiotic resistance, epidemiology and clinical cases: a study of the MDR Klebsiella bacterium and the carbapenems class

, 2022
reservedLa resistenza alla classe dei carbapenemi è un grave problema di salute globale, dato il loro utilizzo come trattamento di ultima linea per molte infezioni causate da microrganismi MDR.
MORETTO, BEATRICE
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Incidence, risk factors and clinical outcomes of patients with hypermucoviscoid Klebsiella in a tertiary intensive care unit

Journal of Global Infectious Diseases, 2020
Background and Objectives: Hypermucoviscoid Klebsiella(hvKP), a dreaded variant of Klebsiella, so far, fewer cases were reported from the community. This study was designed to evaluate the incidence of hvKP isolates, risk factors for hvKP infections ...
Vimal Bhardwaj, Vellaichamy Muthupandi Annapandian, Annie Rofeena Sinazer, Arjun Alva, Shiva Prasad   +4 more
doaj   +1 more source

Hypervirulent Klebsiella pneumoniae [PDF]

Clinical Microbiology Reviews, 2019
Hypervirulent K. pneumoniae (hvKp) is an evolving pathotype that is more virulent than classical K. pneumoniae (cKp). hvKp usually infects individuals from the community, who are often healthy.
Thomas A, Russo, Candace M, Marr
openaire   +2 more sources

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

The importance of pathogenicity factors of some Streptococcus spp. and Klebsiella spp. in determining their etiological role in the inflammatory processes of the respiratory tract

Инфекция и иммунитет, 2020
Together with the known pathogens of inflammatory processes of the respiratory tract in clinical practice are often found representatives of Streptococcus and Klebsiella, previously considered commensals of the mucous membranes of the upper respiratory ...
L. A. Kraeva, E. S. Kunilova, O. A. Burgasova, G. N. Hamdulaeva, E. M. Danilova, G. I. Bespalova   +5 more
doaj   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Antibacterial Activity of Cell-Free Supernatants of Probiotic Lactobacillus against Bacterial Pathogens Associated with Vaginal Infections

Journal of Pure and Applied Microbiology
Vaginal infections are common female disease conditions that account for the prevalence of gynecological disorders which facilitate the increasing antimicrobial resistance and failure of prevalent treatment choices.
Gift Nzubechi Elughi, Margaret Ikiwili Oniha, Yemisi Dorcas Obafemi, Abimbola David Akinyosoye, Eze Frank Ahuekwe, Paul Akinniyi Akinduti   +5 more
doaj   +1 more source