Results 41 to 50 of about 184,541 (309)

Draft Genome Sequences of Four NDM-1-Producing Klebsiella pneumoniae Strains from a Health Care Facility in Northern California. [PDF]

, 2015
We report the draft genome sequences of Klebsiella pneumoniae strains from four patients at a northern California health care facility. All strains contained the New Delhi metallo-β-lactamase (NDM1) carbapenemase with extended antibiotic resistance ...
Chaturvedi, Vishnu, Chorny, Ilya, Greninger, Alexander L, Knowles, Susan, Ng, Valerie L   +4 more
core   +1 more source

Management of KPC-producing Klebsiella pneumoniae infections [PDF]

Clinical Microbiology and Infection, 2018
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas.To provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions.PubMed search for relevant publications ...
Bassetti, M.; Giacobbe, D. R.; Giamarellou, H.; Viscoli, C.; Daikos, G. L.; Dimopoulos, G.; De Rosa, F. G.; Giamarellos-Bourboulis, E. J.; Rossolini, G. M.; Righi, E.; Karaiskos, I.; Tumbarello, M.; Nicolau, D. P.; Viale, P. L.; Poulakou, G.   +15 more
openaire   +8 more sources

Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care units: risk factors for progression to infection

Brazilian Journal of Infectious Diseases, 2016
Background: Little is known about factors associated with carbapenem-resistant Klebsiella pneumoniae infections in pediatric patients, who are initally colonized with carbapenem-resistant Klebsiella pneumoniae. Materials and methods: A retrospective case–
Hacer Akturk, Murat Sutcu, Ayper Somer, Derya Aydın, Rukiye Cihan, Aslı Ozdemir, Asuman Coban, Zeynep Ince, Agop Citak, Nuran Salman   +9 more
doaj   +1 more source

364 NOSOCOMIAL NICU KLEBSIELLA INFECTIONS [PDF]

Pediatric Research, 1978
Previous studies have demonstrated the virulence of multiply resistent Klebsiella pneumoniae strains for newborns, but optimal management of nursery outbreaks has not been defined. We have experienced 2 outbreaks of Kanamycin resistent Klebsiella (Serotypes 60 ± 2) in which 13 infants were bacteremic and 72 infants were colonized.
R D Leake, R M Rosenblatt, H Yoshimori, B F Anthony, A W Chow   +4 more
openaire   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Massive Increase, Spread, and Exchange of Extended Spectrum {beta}-Lactamase-Encoding Genes Among Intestinal Enterobacteriaceae in Hospitalized Children With Severe Acute Malnutrition in Niger. [PDF]

, 2011
Background. From the time of CTX-M emergence, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E) have spread worldwide in community settings as well as in hospitals, particularly in developing countries.
Andremont, A, Angebault, C, Armand-Lefèvre, L, Barbier, F, de Rekeneire, N, El Mniai, A, Hugede, H-C, Jacquier, H, Janssens, A-C, Page, A-L, Raskine, L, Ruppé, E, Sayadi, S, Woerther, P-L   +13 more
core   +2 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source