Results 21 to 30 of about 109,518 (258)

Shiga Toxin-Producing E. coli (STEC) from Danish Patients, 1997–2023: Diagnostic Trends and Bacteriological Findings

Microorganisms
Implementation of molecular detection methodology of Shiga toxin-producing Escherichia coli (STEC) in Danish patients began in 1997. Since then, changes in molecular detection methods and diagnostic criteria have led to the present situation, in which ...
Flemming Scheutz, Katrine Grimstrup Joensen, Susanne Schjørring, Bente Olesen, Jørgen Engberg, Hanne Marie Holt, Hans Linde Nielsen, Lars Lemming, Michael Pedersen, Lisbeth Lützen, Marc Trunjer Kusk Nielsen, Kristian Schønning, Eva Møller Nielsen   +12 more
doaj   +1 more source

Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole

BMC Microbiology, 2023
Introduction The emergence of multidrug-resistant Klebsiella pneumoniae in hospitals represents a serious threat to public health. Infections caused by Klebsiella pneumoniae are widespread in healthcare institutions, mainly pneumonia, bloodstream ...
Shokri M. Shafik, Hisham A. Abbas, Nehal Yousef, Moustafa M. Saleh   +3 more
doaj   +1 more source

KlebsiellaInfection in Patients with Thalassemia [PDF]

Clinical Infectious Diseases, 2003
Klebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting
Ha, SY, Chiang, A, Lee, CY, Ho, HK, Luk, CW, Lau, YL, Chan, GCF, Chung, BHY, Lee, TL   +8 more
openaire   +4 more sources

Phenotypic Characterization of Virulence Factors and Antibiogram of Klebsiella pneumoniae Isolates from Various Clinical Samples – A Cross Sectional Study

Journal of Pure and Applied Microbiology, 2022
K. pneumoniae is known to cause hospital and community acquired infections. It is usually associated with upper & lower respiratory infections, septicaemia, urinary tract infection, wound infections, neonatal sepsis, meningitis, and endophthalmitis.
Madhavi S. Hullur, Arvind Natarajan, P.N. Sreeramulu   +2 more
doaj   +1 more source

Management of KPC-producing Klebsiella pneumoniae infections [PDF]

Clinical Microbiology and Infection, 2018
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas.To provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions.PubMed search for relevant publications ...
Bassetti, M.; Giacobbe, D. R.; Giamarellou, H.; Viscoli, C.; Daikos, G. L.; Dimopoulos, G.; De Rosa, F. G.; Giamarellos-Bourboulis, E. J.; Rossolini, G. M.; Righi, E.; Karaiskos, I.; Tumbarello, M.; Nicolau, D. P.; Viale, P. L.; Poulakou, G.   +15 more
openaire   +8 more sources

Ceftriaxone- and ceftazidime-resistant species, , and methicillin-resistant dominate caesarean surgical site infections at Mulago Hospital, Kampala, Uganda

SAGE Open Medicine, 2020
Objectives: The aim of this study was to determine the proportion and mechanism of resistance to ceftriaxone and ceftazidime among Klebsiella species and Escherichia coli and examine the burden of methicillin-resistant Staphylococcus aureus from ...
Yvonne N Wekesa, Fatuma Namusoke, Musa Sekikubo, Dennis Wandera Mango, Freddie Bwanga   +4 more
doaj   +1 more source

364 NOSOCOMIAL NICU KLEBSIELLA INFECTIONS [PDF]

Pediatric Research, 1978
Previous studies have demonstrated the virulence of multiply resistent Klebsiella pneumoniae strains for newborns, but optimal management of nursery outbreaks has not been defined. We have experienced 2 outbreaks of Kanamycin resistent Klebsiella (Serotypes 60 ± 2) in which 13 infants were bacteremic and 72 infants were colonized.
R D Leake, R M Rosenblatt, H Yoshimori, B F Anthony, A W Chow   +4 more
openaire   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2‐Deoxyglucose

Angewandte Chemie, EarlyView.
New approaches to combat antimicrobial‐resistant pathogens are needed. Here, scaffolding a nonmetabolizable sugar (2DG) on a polymer backbone is shown to significantly improve its antimicrobial activity. ABSTRACT With the increasing prevalence of multidrug‐resistant (MDR) pathogens, last‐line therapeutics such as cyclic peptides are insufficient ...
Sungjin Jeon, Xianjin Qin, Marjon Zamani, Ariel L. Furst, Cassandra E. Callmann   +4 more
wiley   +2 more sources

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source