Results 41 to 50 of about 963,380 (254)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Determinação fenotípica e genotípica de beta-lactamases de espetro estendido em Escherichia coli, Klebsiella pneumoniae e enterobacter spp. de pacientes internados no Hospital Universitário Professor Polydoro Ernani de São Thiago (HU/UFSC) [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As enterobactérias são patógenos oportunistas responsáveis por cerca de 70% das infecções urinárias e
Zamparette, Caetana Paes
core  

Prevalence Study of Multi-drug Resistant Klebsiella pneumoniae Strains Isolated from Respiratory Tract Infections

, 2017
Resistant strains of Klebsiella pneumonia are one of the most prevalent cause of nosocomial and especially respiratory tract infections al-around the world.
Besharat Rahimi, Ahmad Vesal
core   +1 more source

Description of Klebsiella spallanzanii sp. nov. and of Klebsiella pasteurii sp. nov. [PDF]

, 2019
Klebsiella oxytoca causes opportunistic human infections and post-antibiotic haemorrhagic diarrhea. This Enterobacteriaceae species is genetically heterogeneous and is currently subdivided into seven phylogroups (Ko1 to Ko4 and Ko6 to Ko8).
Rodrigues, Carla, Feil, Edward J, Kallonen, Teemu, V. S., Merla, Cristina, Thorpe, Harry, A., Kallonen, Teemu V. S., Passet, Virginie, Sassera, Davide, Brisse, Sylvain, Zong, Zhiyong, Feil, Edward,, Corander, Jukka, Kallonen, Teemu, Feil, Edward, J., Corbella, Marla, Feil, Edward J., Kallonen, Teemu V.S., Marone, Piero, Bandi, Claudio, Thorpe, Harry,, Kallonen, Teemu V S, Corbella, Marta, Sassera, David, Thorpe, Harry A, Kallonen, Teemu,, Thorpe, Harry A., Zhiyong, Zong   +26 more
core   +1 more source

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Neonatal enteral feeding tube as loci for Enterobacteriaceae colonisation and risk to neonatal health [PDF]

, 2014
The incidence of neonatal infections caused by Enterobacteriaceae has been increasing in recent years, and they are now recognised as the predominant causative agents in neonatal intensive care unit (NICU) outbreaks. Klebsiella spp. and Serratia spp. are
Abudalla, H
core  

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections [PDF]

Klebsiella pneumoniae is a Gram-negative bacterium commonly associated with bloodstream infections (BSIs), which can lead to severe clinical outcomes, especially in immunocompromised individuals or patients with underlying health conditions.
Eliana Costa, Igrejas, Gilberto [0000-0002-6365-0735], Sara Sousa, Costa, Eliana, Caniça, Manuela [0000-0002-2077-6231], Carolina Sabença, Rani Rivière, Carmen Torres, Silva, Vanessa, Vanessa Silva, Sabença, Carolina, Torres, Carmen [0000-0003-3709-1690], Manuela Caniça, Rivière, Rani, Poeta, Patrícia [0000-0003-0925-689X], Gilberto Igrejas, Patrícia Poeta, Sousa, Sara   +17 more
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