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Kleine–Levin Syndrome: A case report [PDF]
Sleep Science, 2014 The Kleine–Levin Syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of ...
Taís Figueiredo de Araújo Lima +9 more
doaj +6 more sources
Kleine-Levin syndrome: a review
Nature and Science of Sleep, 2014 Mitchell G Miglis, Christian Guilleminault Stanford University Sleep Medicine Division, Stanford Outpatient Medical Center, Redwood City, CA, USA Abstract: Kleine-Levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia ...
Mitchell Miglis
exaly +7 more sources
SARS-CoV-2 Infection Causes Relapse of Kleine-Levin Syndrome: Case Report and Review of Literature [PDF]
Neurology International, 2021 Recurrent episodes of hypersomnia, hypersexuality, compulsive eating, behavioral and cognitive disturbances, are the basic clinical features of Kleine-Levin syndrome (KLS).
Marino Marčić, Ljiljana Marčić
exaly +4 more sources
An Update on Kleine-Levin Syndrome. [PDF]
Curr Sleep Med Rep, 2023 Kleine-Levin syndrome (KLS) is a rare relapsing-remitting sleep disorder distinguished by recurrent periods of severe hypersomnia accompanied by cognitive, mood, and behavioral changes. This review focuses mainly on the most recent developments and articles concerning this illness in the preceding five years while attempting to provide a basic overview
Qasrawi SO, BaHammam AS.
europepmc +3 more sources
Proteomic biomarkers of Kleine-Levin syndrome. [PDF]
Sleep, 2022 AbstractStudy ObjectivesKleine–Levin syndrome (KLS) is characterized by relapsing–remitting episodes of hypersomnia, cognitive impairment, and behavioral disturbances. We quantified cerebrospinal fluid (CSF) and serum proteins in KLS cases and controls.MethodsSomaScan was used to profile 1133 CSF proteins in 30 KLS cases and 134 controls, while 1109 ...
Hédou J +15 more
europepmc +4 more sources
European Psychiatry, 2021 Introduction Kleine-Levin Syndrome (KLS) is an extremely rare disorder of unknown etiology. It affects mainly male adolescents and is thought to follow a relapse-remitting course.
R. Mota Freitas, M.T. Valadas
doaj +2 more sources
Kleine − Levin syndrome: An ayurvedic perspective
Indian Journal of Ayurveda and Integrative Medicine KLEU, 2022 Kleine − Levin syndrome (KLS), also known as sleeping beauty syndrome, is characterized by the classic triad of hypersomnia, hyperphagia, and hypersexuality. It is an intriguing and severe disease with no clear etiology or management.
Prasad Mamidi, Kshama Gupta
doaj +2 more sources
Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options [PDF]
Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit +2 more
wiley +2 more sources
New‐onset Kleine–Levin syndrome following COVID‐19 infection: A case report [PDF]
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 3, September 2025.Abstract Background Kleine–Levin syndrome (KLS) is a rare sleep disorder marked by recurrent episodes of severe hypersomnolence with accompanying cognitive, behavioral, or mood disturbances. Infections are frequently reported before symptom onset and have been proposed as potential triggers, although a definitive causal relationship has not been ...
Daisuke Yoshioka +2 more
wiley +2 more sources
Systematic Assessment of Dysexecutive Syndrome, Hypersomnolence and Dysautonomia in Kleine‐Levin Syndrome [PDF]
European Journal of Neurology, Volume 32, Issue 7, July 2025.ABSTRACT Background Kleine‐Levin Syndrome (KLS) is a neurological disorder of unknown pathophysiology. It is characterized by relapsing–remitting episodes of hypersomnia, with cognitive symptoms and behavioral disturbances. The diagnosis relies on clinical criteria, which require further standardization.
Lucie Barateau +6 more
wiley +2 more sources