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Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia and other symptoms and it is a really challenging for the physician, since its causes are not yet clear, and available treatment options are not having adequate support ...
Naresh Nebhinani +2 more
doaj +1 more source
Successful long-term management of a child with Kleine-Levin syndrome with low-dose lithium
Kleine-Levin syndrome (KLS) is a rare disorder characterized by episodic hypersomnia along with cognitive and behavioral disturbances (i.e., hyperphagia and hypersexuality). It is commonly seen in a young male.
Arpit Parmar +3 more
doaj +1 more source
The cytonuclear interactions during grapevine domestication
Analysis of the grapevine pan‐mitochondrial genome reveals extensive structural variation, and shows that nuclear‐mitochondrial segments promote cytonuclear interaction during grapevine domestication, offering insights into the effect of cytonuclear interactions on plant evolution, genetics, and breeding.
Ting Hou +29 more
wiley +1 more source
Kleine-Levin syndrome (KLS) is a rare illness of recurrent episodes of hypersomnia associated with hyperphagia, cognitive dysfunctions and behavioural abnormalities. KLS, a disorder often reported in young males has been described in fewer females. It is
Prabhoo Dayal +2 more
doaj +1 more source
Actigraphy against 32‐hour polysomnography in patients with suspected idiopathic hypersomnia
Summary Actigraphy, a tool known for investigating sleep–wake patterns at home, lacks scientific validation in hypersomnolent subjects. We aim to validate an actigraphy‐based sleep–wake prediction algorithm against 32‐h continuous polysomnography in patients with suspected idiopathic hypersomnia, and to compare its performance to predict sleep–wake ...
Tugdual Adam +3 more
wiley +1 more source
Present and Future of Central Disorders of Hypersomnolence
ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini +4 more
wiley +1 more source
We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described.
Luís Pereira Justo +3 more
doaj +1 more source
Sleep Medicine—What's in a Name?
ABSTRACT Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence‐based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well‐being.
Dirk A. Pevernagie +7 more
wiley +1 more source
The Treatment of Kleine-Levin Syndrome with Lithium*
A case of Kleine-Levin Syndrome without megaphagia is described in an adolescent male who responded well to lithium treatment. Seventy-two hours of sleep monitoring during a typical attack revealed decreased stages three and four but no sleep-onset REM ...
Mark A. Goldberg
core +1 more source
Kleine-Levin Syndrome Response to Carbamazepine
A 16-year-old male adolescent began having recurrent episodes of severe hypersomnia which persisted 5 or 6 times a year up to age 27, when he was treated with carbamazepine at the American University of Beirut, Medical Center, Lebanon.
J Gordon Millichap
doaj +1 more source

