Results 51 to 60 of about 1,328,941 (179)

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Pharmacological treatment for Kleine-Levin syndrome

, 2013
BackgroundThis is an updated version of the original Cochrane review, published in Issue 2, 2009.Kleine-Levin syndrome (KLS) is a rare disorder that mainly affects adolescent men.
Cristiane Conti, Gilmar F Prado, Marcio M Oliveira, Oliveira, Márcio Moysés de [UNIFESP], Prado, Gilmar Fernandes do [UNIFESP], Conti, Cristiane Fiquene [UNIFESP]   +5 more
core   +1 more source

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

Kleine-Levin Syndrome in a Female Patient

, 1976
A female patient suffering from Kleine-Levin Syndrome is described. The clinical picture of hypersomnia with compulsive eating, leading to obesity, coupled with a marked change in personality make-up (characterized by episodes of confusion, perplexity ...
Denis Cronin, Lal B. Takrani
core   +1 more source

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers   +4 more
wiley   +1 more source

A 5-year follow-up of a female patient with Kleine-Levin syndrome: Diagnosis,disease course and management

Rare, 2023
Kleine-Levin syndrome (KLS) is a rare illness of recurrent episodes of hypersomnia associated with hyperphagia, cognitive dysfunctions and behavioural abnormalities. KLS, a disorder often reported in young males has been described in fewer females. It is
Prabhoo Dayal, Virendra Vikram Singh, Ravikant Kumar   +2 more
doaj   +1 more source

Actigraphy against 32‐hour polysomnography in patients with suspected idiopathic hypersomnia

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
Summary Actigraphy, a tool known for investigating sleep–wake patterns at home, lacks scientific validation in hypersomnolent subjects. We aim to validate an actigraphy‐based sleep–wake prediction algorithm against 32‐h continuous polysomnography in patients with suspected idiopathic hypersomnia, and to compare its performance to predict sleep–wake ...
Tugdual Adam, Jérôme Tanty, Lucie Barateau, Yves Dauvilliers   +3 more
wiley   +1 more source

Kleine-Levin Syndrome Response to Carbamazepine

Pediatric Neurology Briefs, 2009
A 16-year-old male adolescent began having recurrent episodes of severe hypersomnia which persisted 5 or 6 times a year up to age 27, when he was treated with carbamazepine at the American University of Beirut, Medical Center, Lebanon.
J Gordon Millichap
doaj   +1 more source

Present and Future of Central Disorders of Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Sleep Medicine—What's in a Name?

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence‐based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well‐being.
Dirk A. Pevernagie, Erna Sif Arnardottir, Oliviero Bruni, Sarah Hartley, Gert Jan Lammers, Tiina Paunio, Dieter Riemann, Renata L. Riha   +7 more
wiley   +1 more source