Results 181 to 190 of about 11,628 (203)
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Regulation of KLF2 in the Thymus
The FASEB Journal, 2008Our laboratory has identified the transcription factor Krüppel‐like factor 2 (KLF2) as an important regulator of T cell migration. KLF2 deficient T cells mature normally but are retained in thymus. KLF2 controls the expression of receptors such as S1P 1 and CD62L in T cells. The regulation of
Michael Alexander Weinreich +2 more
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KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2020 Neutrophils are key inflammatory cells in the immunopathogenesis of asthma. Neutrophil migration can be initiated through activation of the CXCR1 and CXCR2 receptors by CXC chemokines, such as IL-8. Although transcription factor KLF2 has been found to maintain T cell migration patterns through repression of several chemokine receptors, whether KLF2 can
Fang-Fang Dai, Yu-Zhu Li, Zi Wang
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KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 Objective-Atheroprotective blood flow induces expression of anti-inflammatory Kruppel-like factor 2 (KLF2) and activates antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in vascular endothelium.
Joost O Fledderus +2 more
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Role of KLF2: New insight in inflammatory acne pathogenesis
Journal of Cosmetic Dermatology, 2020AbstractBackgroundAcne is an inflammatory skin condition of pilosebaceous unit. Its pathogenesis is multifactorial with a central role of inflammatory and pro‐inflammatory cytokines mediators. Downregulated Kruppel‐like factor 2 (KLF2) leads to rapid secretion of many cytokines that are involved in acne pathogenesis.AimsThis study aimed at evaluating ...
Menha A. Ibrahim +2 more
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FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation [PDF]
Cell Research, 2013 F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCF(FBW7) (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological processes. Although FBW7 is required for vascular development, its function in the endothelium remains to be investigated.
Ren Chunguang, Chen Yunfei, Fu Cong
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Transcription Factor KLF2 and Its Role in the Regulation of Inflammatory Processes
Biochemistry (Moscow), 2020KLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells.
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Beyond the biofilm: KLF2 as a molecular gatekeeper in periodontal health and disease
OdontologyPeriodontal disease is a chronic inflammatory condition resulting from complex interactions between microbial dysbiosis and host immune responses, leading to progressive destruction of the periodontium. Kruppel-like factor 2 (KLF2), a zinc-finger transcription factor, has emerged as a key regulator of immune modulation and tissue homeostasis.
Sreejith Krishna +3 more
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