Results 131 to 140 of about 54,134 (244)

NKX2.2 and KLF4 cooperate to regulate α cell identity

Genes & Development
Abstract Transcription factors (TFs) are indispensable for maintaining cell identity through regulating cell-specific gene expression. Distinct cell identities derived from a common progenitor are frequently perpetuated by shared TFs; yet the mechanisms that enable these TFs to regulate cell-specific targets are ...
Elliott P. Brooks, McKenna R. Casey, Kristen L. Wells, Tsung-Yun Liu, Madeline Van Orman, Lori Sussel   +5 more
openaire   +2 more sources

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Overexpression of DNA demethylase ten-eleven translocation 3 mediates high expression of Krüppel-like factor 4 in the skin lesions of patients with psoriasis vulgaris

陆军军医大学学报
Objective To investigate the molecular mechanism of DNA methylation of the abnormally high expression of Krüppel-like factor 4 (KLF4) in psoriasis vulgaris lesions.
ZHANG Shuai, LUO Wen, ZHANG Lian
doaj   +1 more source

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Breast cancer cell‐derived stem cell factor (SCF) activates c‐KIT‐mediated MAPK/ERK signaling in mast cells, inducing IFNB1 production. Mast cell‐derived IFNB1 then engages the IFNAR1‐STAT1 axis in breast cancer cells, activating the Type I interferon pathway to promote tumor stemness and progression.
Siqin Li, Juchuanli Tu, Ruoyi Ding, Xueyan He, Xian Zhang, Mengxue Dong, Fengkai Li, Wen Yi, Yuwei Tao, Wei Ma, Zhijun Dai, Zhenhua Chen, Yuan Wang, Xiongbin Lu, Jian Liu, Suling Liu, Jiahui Xu   +16 more
wiley   +1 more source

Elevated desmoglein‐2 expression in multiple myeloma is a prognostic marker across genomic subtypes with impact on high‐risk cytogenetics and a distinct gene expression profile

British Journal of Haematology, EarlyView.
Barbara J. McClure, John Toubia, Charlotte E. J. Toomes, O. Giles Best, Angelina Yong, Cindy H. Lee, Claudine S. Bonder, Chung Hoow Kok   +7 more
wiley   +1 more source

Zinc‐Coordination‐Driven Pyroptosis Nano‐Inductor Sensitizes Colorectal Cancer Chemo‐Immunotherapy by Specific Delivery and Cell Stemness Suppression

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CD44‐targeted CNPs co‐deliver Zn2+ and MIT–ALA to CRC cells. Intracellularly, Zn2+ inhibits GLUT1‐dependent glycolysis, and ALA disrupts mitochondrial function, driving metabolic exhaustion in CSCs. This mitochondrial damage primes GSDMD‐mediated pyroptosis, accompanied by the release of pro‐inflammatory cytokines (IL‑1β, IL‑18).
Qinxia Chang, Wenting Cheng, Hailong Tian, Siyuan Qin, Yaying Zhang, Jing Zuo, Wenbing Pu, Shuaijun Lu, Na Xie   +8 more
wiley   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source