Results 141 to 150 of about 54,134 (244)

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

Tumor Electric Field Therapy Inhibits Epithelial‐Mesenchymal Transition, Invasion, and Migration of Glioblastoma by Targeting the c‐FOS/CXCL14 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Integrated multi‐omics screening identified CXCL14 as a TEFT target. Functional validation via knockdown/overexpression in GBM cells confirmed its role in migration, invasion, and EMT. Mechanism studies revealed TEFT suppresses EMT via the c‐FOS/CXCL14 axis, validated in orthotopic mouse models and clinical samples.
Cheng Sun, Yuyang Liu, Junyi Chen, Jie Pei, Chao Li, Jinxin Lan, Er Wen, Jialin Liu, Ze Li, Ling Chen   +9 more
wiley   +1 more source

Sleep Deprivation Exacerbates Ischemic Stroke Outcomes via Akkermansia Depletion and Metabolic Dysregulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Under ABX‐induced gut dysbiosis, sleep deprivation reduces beneficial taxa and enriches pro‐inflammatory bacteria, leading to increased intestinal permeability and amplified peripheral inflammation, thereby exacerbating BBB disruption and neuroinflammation and worsening ischemic brain injury.
Xin Nie, Sheng‐Yang Zhou, Le Yao, Lu‐Lu Tan, Xiao‐Yu Ma, Yi‐Meng Xia, Chun Cui, Wei‐Jiang Zhao, Chen‐Meng Qiao, Yan‐Qin Shen, Chao‐Sheng Li   +10 more
wiley   +1 more source

A-Lister: a tool for analysis of differentially expressed omics entities across multiple pairwise comparisons. [PDF]

, 2019
BackgroundResearchers commonly analyze lists of differentially expressed entities (DEEs), such as differentially expressed genes (DEGs), differentially expressed proteins (DEPs), and differentially methylated positions/regions (DMPs/DMRs), across ...
Listopad, Stanislav A, Norden-Krichmar, Trina M   +1 more
core   +1 more source

Consolidating Clinical Insights and Uncovering Novel Regulatory Mechanisms of Exosomal MicroRNAs in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease: A Systematic Review and Bioinformatics Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Clinical studies identified 93 obesity‐associated and 24 NAFLD‐associated exosomal miRNAs, with let‐7b and miR‐335‐5p emerging as common nodes. Bioinformatics analysis revealed extensive overlap at the functional level, including 40,410 shared miRNA‐mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals,
Qigui Mo, Amirreza Ghafourian, Masoomeh Hamdi, Arian Alidadipour, Mahdieh Soleimani, Maryam Davoudi, Xiaolei Miao, Reza Afrisham, Molood Bagherieh   +8 more
wiley   +1 more source

Genotype–Phenotype Discordance in Cardiomyopathies: Pathophysiology, Clinical Expression, and Therapeutic Considerations

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Cardiomyopathies encompass a spectrum of myocardial disorders often attributed to underlying genetic mutations. However, genotype–phenotype discordance where the genetic profile does not align with the expected clinical presentation poses significant diagnostic, prognostic, and therapeutic challenges.
Abubakar Nazir, Atif Hussain Sarwar, Rameen Nazar, Sarim Hassan Shahab, Sumera Manan, Hafsa Rafique, Ahsan Talal Khan, Abdalhakim Shubietah, Syed Rafay Hussain Zaidi, Behram Khan   +9 more
wiley   +1 more source

Gene expression profiling, prognosis, and immune microenvironment of KLF4 in malignancies.

PLoS ONE
Gene expression profiling plays a crucial role in understanding the role of Krüppel-like factor 4 (KLF4) in the prognosis and tumor immune microenvironment of various malignancies.
Shoukai Yu, Lingmei Qian, Tianlang Tong, Xujun Ma   +3 more
doaj   +1 more source

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation. [PDF]

, 2019
Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine.
Iacovino, Michelina, Iribarren, Carlos, Krauss, Ronald M, Kuang, Yu-Lin, Mattis, Aras N, Medina, Marisa W, Munoz, Antonio, Nalula, Gilbert, Sanchez, Gabriela, Sanghez, Valentina, Santostefano, Katherine E, Terada, Naohiro   +11 more
core  

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

MedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang, Jianheng Zhu, Xiang Peng, Kanghua Zhong, Ming Zou, Xi Yang, Qiuhua Wang, Changjun Nie, Chaorui Tang, Ning Tang, Lanlan Geng, Hanhan Chen, James E. Vince, Hirokazu Kanegane, Xiaodong Zhao, Huifang Xian, Wenhao Zhou, Min Zhi, Yuxia Zhang, Zhanghua Chen   +28 more
wiley   +1 more source

KLF4 and CD55 expression and function depend on each other

Frontiers in Immunology
The transcription factor Kruppel-like factor 4 (KLF4) regulates the expression of immunosuppressive and anti-thrombotic proteins. Despite its importance in maintaining homeostasis, the signals that control its expression and the mechanism of its transactivation remain unclarified.
An, Feng-Qi, Zhou, Guangjin, Harland, Micah T., Hussain, Wasim, Strainic, Michael G., Jain, Mukesh K., Medof, M. Edward   +6 more
openaire   +3 more sources