Results 161 to 170 of about 33,787 (326)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue [PDF]

, 2018
Fibroblast growth factor 21 (FGF21) has been proposed to be an antiaging hormone on the basis of experimental studies in rodent models. However, circulating FGF21 levels are increased with aging in rodents and humans.
Barzilai, Cevenini, Coskun, Diaz-Delfin, Fisher, Gaich, Gallego-Escuredo, Gallego-Escuredo, Hanks, Kharitonenkov, Kuroda, Kurosu, Ogawa, Salminen, Sanchis-Gomar, Taniguchi, Zhang   +16 more
core   +3 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Durée de vie, génétique et axe somatotrope [PDF]

, 2006
Longtemps descriptive, la recherche sur le vieillissement a profondément changé depuis la découverte de gènes régulant la durée de vie. Isolés en criblant le génome de simples nématodes, la plupart de ces gènes appartiennent à une voie de signalisation ...
Filho, Carlos De Magalhaes, Holzenberger, Martin, Kappeler, Laurent, Le Bouc, Yves   +3 more
core   +1 more source

Gender-specific association between circulating serum Klotho and metabolic components in adults

BMC Endocrine Disorders
Background Klotho plays a pivotal role in human aging. Metabolic syndrome (MetS) is composed of multiple conditions that are also risk factors for cardiovascular disease and diabetes.
Zhenzhen Wang, Hang Zhang, Guixia Zheng, Zheng Wang, Lei Shi   +4 more
doaj   +1 more source

Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Analytical Cellular Pathology, 2019
Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the α-klotho protein, which has many functions. Previous studies have found that α-klotho protein has a cardiorenal protective function.
Xi Liu, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, Ying Yu, Jieli Huang, Jiangtao Li, Chen Yu   +7 more
doaj   +1 more source

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis and expression of longevity gene Klotho (Microarray dataset)

, 2021
Sandrine Thuret
openalex   +1 more source

Novel Roles of GDF15 in Alleviating Renal Fibrosis: Promoting Autophagy and Lysosome Biogenesis via Inhibition of the PI3K/Akt/mTOR Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Tubulointerstitial fibrosis (TIF) significantly contributes to the development of end‐stage renal disease (ESRD) in chronic kidney disease (CKD). However, the underlying mechanisms driving its development remain poorly understood, thereby impeding the development of effective prevention and treatment strategies. Although growth differentiation
Youqi Li, Jinge Gu, Danping Tao, Haoyang Wu, Chen Yang, Yongjun Shi, Chengwen Huang, Boxun Luo, Jun Zhang   +8 more
wiley   +1 more source

Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease [PDF]

, 2016
Background. Klotho proteins (α- and β) are membrane-based circulating proteins that regulate cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth Factors.
Agrawal, Pratik R., Assanelli, Deodato, Chen-Scarabelli, Carol, Corsetti, Giovanni, Dioguardi, Francesco S., Ferrari-Vivaldi, Mario, Flati, Vincenzo, Knight, Richard, Narula, Jagat, Pasini, Evasio, Romano, Claudia, Saravolatz, Louis, Scarabelli, Tiziano M.   +12 more
core   +2 more sources

Is there a role in acute kidney injury for FGF23 and Klotho? [PDF]

, 2023
Deborah Mattinzoli, Paolo Molinari, Gregorio Romero‐González, Jordi Bover, Elisa Cicero, Francesco Pesce, Matteo Abinti, Costanza Conti, Giuseppe Castellano, Carlo Alfieri   +9 more
openalex   +1 more source

Therapeutic Effects of Gallic Acid and Alpha‐Tocopherol on Adenine‐Induced Chronic Kidney Disease in Male Wistar Rats

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Chronic kidney disease (CKD) is a major health issue associated with oxidative stress and inflammation that leads to progressive renal damage. Natural antioxidants, gallic acid (GA) and alpha‐tocopherol (AT), have gained attention for their strong free radical‐scavenging, inflammation‐reducing, and tissue‐repairing properties, and their individual or ...
Momita Rani Baro, Manas Das, Kishore Sarma, Leena Das, Aashis Dutta, Ananya Chetia, Pliza Kalita, Sushil Nagar   +7 more
wiley   +1 more source