Association of High-Density Lipoprotein Subclasses with Chronic Kidney Disease Progression, Atherosclerosis, and Klotho. [PDF]
PLoS ONE, 2016 Atherosclerosis is often a complication of chronic kidney disease (CKD) because of dyslipidemia and CKD-mineral and bone disorder. High-density lipoproteins (HDLs) are grouped into various subclasses composed of multiple proteins and lipids, and their ...
Eiichiro Kanda +4 more
doaj +1 more source
The Relationship between Early Stage of Diabetic Nephropathy and Soluble Klotho Proteins: A Systematic Review and a Network Meta-Analysis [PDF]
, 2022 Yushan Li +6 more
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Journal of Animal Physiology and Animal Nutrition, EarlyView.ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall +4 more
wiley +1 more source
Vitamin D reduces inflammatory response in hypertensive mice with early renal injury [PDF]
Jichu yixue yu linchuangObjective To investigate the underlying mechanisms of vitamin D treatment improves early-stage renal damage in hypertensive mice. Methods From December 2022 to December 2023, peripheral blood samples were collected from 20 hypertensive patients with ...
ZHANG Junshi, LIU Haiming, CHEN Xi
doaj +1 more source
Liraglutide increases FGF-21 activity and insulin sensitivity in high fat diet and adiponectin knockdown induced insulin resistance. [PDF]
PLoS ONE, 2012 BACKGROUND: Liraglutide is a glucagon-like peptide-1 analogue that stimulates insulin secretion and improves β-cell function. However, it is not clear whether liraglutide achieves its glucose lowering effect only by its known effects or whether other as ...
Mengliu Yang +6 more
doaj +1 more source
Alkaline phosphatases in the complex chronic kidney disease-mineral and bone disorders [PDF]
, 2018 Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they
Aguilar, Armando +8 more
core +1 more source
Journal of Periodontal Research, EarlyView.Effects of exogenous tissue‐nonspecific alkaline phosphatase (TNAP) were analyzed in the Hyp mouse model of X‐linked hypophosphatemia (XLH). Maxillary first molars were extracted from wild‐type (WT) and Hyp mice at 6 weeks, and collagen gel ± TNAP was placed in sockets. In one group of Hyp mice, submucosal injections of TNAP or saline were delivered at
Aonjittra Phanrungsuwan +3 more
wiley +1 more source
Nuclear localization of Klotho in brain: an anti-aging protein [PDF]
Neurobiology of Aging, 2012 Klotho is a putative age-suppressing gene whose overexpression in mice results in extension of life span. The Klotho gene encodes a single-pass transmembrane protein whose extracellular domain is shed and released into blood, urine, and cerebrospinal fluid, potentially functioning as a humoral factor.
Dwight C, German +4 more
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Relationship between serum fibroblast growth factor 19 and vascular endothelial growth factor and soluble klotho protein in type 1 diabetic children [PDF]
, 2023 Yanjun Zhang +7 more
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Experimental Physiology, EarlyView.Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu +4 more
wiley +1 more source