Results 111 to 120 of about 12,957 (269)
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]
, 2013 Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau +2 more
core +1 more source
Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity
Lifestyle Medicine, Volume 7, Issue 1, January 2026.ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien +4 more
wiley +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Klotho protein function among patients with type 1 diabetes
Endokrynologia Polska, 2018 The fibroblast growth factor 23 (FGF23) and Klotho system play a very important role in the regulation of the human body metabolism. On the one hand, they promote longevity, and on the other hand they promote insulin resistance. Nowadays, accelerated aging in diabetes as the main consequence of chronic complications of the disease is postulated ...
Justyna, Flotyńska +3 more
openaire +3 more sources
From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]
, 2015 Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
core +2 more sources
The role of FGF23/Klotho in mineral metabolism and chronic kidney disease [PDF]
, 2013 Chronic kidney disease (CKD) is a global health burden of growing incidence and prevalence. As renal function declines disturbances in mineral metabolism, such as hyperphosphatemia and secondary hyperparathyroidism, inevitably develop. These metabolic
Olauson, Hannes
core +1 more source
Lipids in Health and Disease, 2017 Background Atherosclerosis is a common cardiovascular disease that causes myocardial infarction, heart failure, and stroke. Increased oxidized low density lipoprotein (ox-LDL) in the sub-endothelium is the characteristic origin of atherogenesis.
Yansheng Yao +3 more
doaj +1 more source
Durée de vie, génétique et axe somatotrope [PDF]
, 2006 Longtemps descriptive, la recherche sur le vieillissement a profondément changé depuis la découverte de gènes régulant la durée de vie. Isolés en criblant le génome de simples nématodes, la plupart de ces gènes appartiennent à une voie de signalisation ...
Filho, Carlos De Magalhaes +3 more
core +1 more source
Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. [PDF]
, 2016 Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER).
Hrabovszky, E. +5 more
core +1 more source
Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies [PDF]
, 2016 Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a dominant factor. Thus, regardless
Li, Meng
core +1 more source