Results 121 to 130 of about 12,957 (269)

Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury [PDF]

, 2020
Agnieszka Olejnik, Anna Krzywonos‐Zawadzka, Marta Banaszkiewicz, Iwona Bil‐Lula   +3 more
openalex   +1 more source

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells [PDF]

, 2017
Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs).
Alesutan, Ioana, Castor, Tatsiana, Feger, Martina, Kratschmar, Denise V., Mia, Sobuj, Sacherer, Michael [u.a.], Voelkl, Jakob   +6 more
core   +1 more source

The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease

, 2021
Milan Zimmermann, Leonie Köhler, Markéta Kovářová, Stefanie Lerche, Claudia Schulte, Isabel Wurster, Gerrit Machetanz, Christian Deuschle, Ann‐Kathrin Hauser, Thomas Gasser, Daniela Berg, Erwin Schleicher, Walter Maetzler, Kathrin Brockmann   +13 more
openalex   +1 more source

The Association Between Circulating Klotho and Dipeptidyl Peptidase-4 Activity and Inflammatory Cytokines in Elderly Patients With Alzheimer Disease

Basic and Clinical Neuroscience, 2020
Introduction: Klotho and dipeptidyl peptidase-4 (DPP4) are two proteins that modulate inflammatory pathways. We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-
Mohsen Sedighi, Tourandokht Baluchnejadmojarad, Soudabeh Fallah, Nariman Moradi, Siamak Afshin-Majd, Mehrdad Roghani   +5 more
doaj  

Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]

, 2016
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik, Kalló, Imre, Liposits, Zsolt, Solymosi, Norbert, Sárvári, Miklós   +4 more
core   +1 more source

Associations of KLOTHO-VS heterozygosity and α-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers

Journal of Alzheimer’s Disease
Background KLOTHO -VS heterozygosity ( KL -VSHET) and soluble α-Klotho (sαKl) protein interfere with Alzheimer's disease (AD) pathophysiology, but the specific relationships remain unclear.
Alzbeta Katonova, Ross Andel, Vanesa Jurasova, Katerina Veverova, Francesco Angelucci, Vaclav Matoska, Jakub Hort   +6 more
openaire   +2 more sources

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]

, 2019
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen, Flores, Ivan, Ramos, Julian, Tidball, James G, Wang, Ying, Wehling-Henricks, Michelle, Welc, Steven S   +6 more
core  

Klotho protein lowered in elderly hypertension.

International journal of clinical and experimental medicine, 2014
We intend to identify the relationship between Klotho protein and elderly hypertension. Serous Klotho protein and nitric oxide (NO) which gathered from 79 elderly hypertensive patients, 30 elderly non-hypertensive patients and 25 non-elderly hypertensive patients were detected by ELISA and nitro-reductase method, respectively; and the comparison came ...
Xian-Ming, Su, Wei, Yang
openaire   +1 more source

The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis

Clinical Interventions in Aging, 2020
Edyta Zbroch, 1 Angelika Bazyluk, 1 Jolanta Malyszko, 2 Ewa Koc-Zorawska, 1 Alicja Rydzewska-Rosolowska, 1 Katarzyna Kakareko, 1 Tomasz Hryszko 1 1 2-nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Zbroch E, Bazyluk A, Malyszko J, Koc-Zorawska E, Rydzewska-Rosolowska A, Kakareko K, Hryszko T   +6 more
doaj  

Fasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho

BMC Nephrology
Background The renal renin-angiotensin system (RAS) plays a vital part in the control of blood pressure and is known to be affected by aging. This study aimed to investigate the effects of intermittent fasting on age-related hypertension and the ...
Firuzeh Badreh, Siyavash Joukar, Mohammad Badavi, Mohammad Rashno   +3 more
doaj   +1 more source