Results 131 to 140 of about 12,957 (269)

Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet

Frontiers in Cardiovascular Medicine, 2019
The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed light on the consequences of loss-of-function mutations for different ...
Magnus Bäck, Tamas Aranyi, M. Leonor Cancela, Miguel Carracedo, Natércia Conceição, Georges Leftheriotis, Vicky Macrae, Ludovic Martin, Yvonne Nitschke, Andreas Pasch, Daniela Quaglino, Frank Rutsch, Catherine Shanahan, Victor Sorribas, Flora Szeri, Flora Szeri, Pedro Valdivielso, Olivier Vanakker, Hervé Kempf   +18 more
doaj   +1 more source

In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy

Frontiers in Pharmacology
BackgroundEpilepsy and seizures are characterized by neuronal hyperexcitability and damage, influenced by metabolic dysregulation, neuroinflammation, and oxidative stress.
Mansi Dahalia, Mansi Dahalia, Haya Majid, Mohd Junaid Khan, Akshat Rathi, Mohd Ashif Khan, Imran Ahmd Khan, Mohammed Samim, Sayeed Ur Rehman, Md Salik Noorani, Divya Vohora, Nidhi   +11 more
doaj   +1 more source

High-intensity physical exercise increases serum -klotho levels in healthy volunteers

Journal of Circulating Biomarkers, 2018
The recently discovered klotho proteins have roles in a diverse range of metabolic processes with the oldest protein, α-klotho, implicated in various cellular pathways in energy, glucose, and phosphate metabolism.
Sven-Jean Tan, Melissa M Chu, Nigel D Toussaint, Michael MX Cai, Tim D Hewitson, Stephen G Holt   +5 more
doaj   +1 more source

Vascular Calcification in Patients with Chronic Kidney Disease: Types, Clinical Impact and Pathogenesis [PDF]

, 2013
Vascular calcification plays a major role in cardiovascular disease, which is one of the main causes of mortality in chronic kidney disease patients. Vascular calcification is determined by prevalent traditional and uraemia-related (non-traditional) risk
Cabezas-Rodríguez, Iván, Cannata, J.B. (Jorge), Díaz-López, Bernardino, López-Ongil, Susana, Rodríguez-García, Minerva, Román-García, Pablo   +5 more
core  

Abnormal Histopathological Expression of Klotho, Ferroptosis, and Circadian Clock Regulators in Pancreatic Ductal Adenocarcinoma: Prognostic Implications and Correlation Analyses

Biomolecules
Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal tumor with increasing incidence, presenting numerous clinical challenges. The histopathological examination of novel, unexplored biomarkers offers a promising avenue for research, with ...
Cielo García-Montero, Oscar Fraile-Martinez, David Cobo-Prieto, Diego De Leon-Oliva, Diego Liviu Boaru, Patricia De Castro-Martinez, Leonel Pekarek, Raquel Gragera, Mauricio Hernández-Fernández, Luis G. Guijarro, María Del Val Toledo-Lobo, Laura López-González, Raul Díaz-Pedrero, Jorge Monserrat, Melchor Álvarez-Mon, Miguel A. Saez, Miguel A. Ortega   +16 more
doaj   +1 more source

Review of: "[Research Note] Unveiling the Interplay of Klotho Protein, Chemotherapy-Induced Klotho Protein Deficiency, and the Pivotal Role of GLP-1 Agonists like Ozempic in Cancer Survivorship Patient Survival Rate after Chemotherapy Treatment" [PDF]

, 2023
Dorin Drago
openalex   +1 more source

Role of the anti-aging α-KLOTHO protein in chondrocytes [PDF]

, 2021
A. Defois, Nina Bon, Sophie Sourice, Mathieu Mével, Marie Georget, B. Bodic, Oumeya Adjali, Yves Maugars, Jérôme Guicheux, Claire Vinatier   +9 more
openalex   +1 more source

Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection

Viruses
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for causing the Coronavirus disease 2019 (COVID-19) outbreak. While mutations cause the emergence of new variants, the ancestral SARS-CoV-2 strain is unique among
Niharika Bala, Ramish H. Rafay, Sarah C. Glover, Abdel A. Alli   +3 more
doaj   +1 more source

Regulation of phosphate transport in proximal tubules [PDF]

, 2018
Homeostasis of inorganic phosphate (Pi) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered Pi occurs along the renal proximal tubule and is initiated by apically localized Na+-dependent Pi cotransporters.
Biber, J., Forster, I., Hernando, N., Murer, H.   +3 more
core  

Review of: "[Research Note] Unveiling the Interplay of Klotho Protein, Chemotherapy-Induced Klotho Protein Deficiency, and the Pivotal Role of GLP-1 Agonists like Ozempic in Cancer Survivorship Patient Survival Rate after Chemotherapy Treatment" [PDF]

Jinghui Wang
  +6 more sources