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Cerebral Klotho Protein as a Humoral Factor for Maintenance of Baroreflex [PDF]

Hormone and Metabolic Research, 2014
The klotho protein produced by the choroid plexus is known as a humoral factor in central nervous system. Many hormones affecting the baroreflex sensitivity have been introduced in the brain. However, role of klotho in the baroreflex sensitivity is still unknown. Recently, mutations in the klotho gene have been linked to cardiovascular diseases in both
M.-F. Cheng, Juei-Tang Cheng, Juei-Tang Cheng, P.-M. Ku, Li-Jen Chen   +4 more
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Role of Klotho, an antiaging protein, in pulmonary fibrosis

Archives of Toxicology, 2014
Klotho is a recently discovered antiaging protein. Although many researchers are investigating the roles of Klotho in chronic kidney diseases and cancer, however, there are no studies on the roles of Klotho in chronic pulmonary diseases. The purpose of this study was to define the role of Klotho in pulmonary fibrosis using a murine model of ovalbumin ...
Jong-Choon Kim, In-Sik Shin, Mee-Young Lee, Hyeun-Kyoo Shin   +3 more
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Klotho Protein Protects against Endothelial Dysfunction

Biochemical and Biophysical Research Communications, 1998
Arteriosclerosis caused by aging is recognized to be a crucial risk factor of cardiovascular disease. We recently established klotho mouse which causes age-related disorders including arteriosclerosis. However, no information on endothelial function of klotho mouse or the physiological role of klotho protein as a circulating factor is available.
Tatsuo Suga, Masahiko Kurabayashi, Yo-ichi Nabeshima, Hiroki Aizawa, Ryozo Nagai, Takahiro Yamagishi, Matsumura Yutaka, Yoshio Ohyama, Makoto Kuro-o, Yuichiro Saito, Tetsuya Nakamura, Hiroaki Masuda   +11 more
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Klotho Is a Neuroprotective and Cognition-Enhancing Protein

2016
In this chapter, we will describe what has been learned about Klotho and its potential functions in the brain. Klotho is localized in the choroid plexus and, to a lesser extent, in hippocampal neurons. Cognitive decline is a common issue in human aging affecting over 50% of the population.
P C Mullen, Ella Zeldich, T Tucker-Zhou, Carmela R. Abraham, Ci-Di Chen   +4 more
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Klotho-Related Protein KLrP

2016
Klotho (KL) family proteins share one or two glycoside hydrolase (GH) motifs homologous to GH family 1. However, the biological significance of GH motifs in KL family proteins remains elusive. We describe here that KL-related protein (KLrP), which is composed of a single GH motif, is a cytosolic β-glucocerebrosidase (GCase, EC 3.2.1.145). We detected a
Makoto Ito, Yasuhiro Hayashi
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α-Klotho protein in neurodegenerative and mental diseases

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019
The review aims to attract attention of psychiatrists and neurologists to a role of α-Klotho protein in biochemical mechanisms that counteract pathogenic processes of neurodegenerative and psychiatric diseases and to possible therapeutic potential of the protein.
E B Tereshkina, G. Sh. Burbaeva, Savushkina Ok, I. S. Boksha, T A Prokhorova   +4 more
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Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review

Indian Journal of Clinical Biochemistry, 2022
Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho is a single pass transmembrane protein that decreases with age, has been associated with various ...
Amandeep Birdi, Sojit Tomo, Dharmveer Yadav, Praveen Sharma, Naresh Nebhinani, Prasenjit Mitra, Mithu Banerjee, Purvi Purohit   +7 more
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The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice

European Journal of Pharmacology, 2013
Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. Nonetheless, the related mechanisms were still unknown. Many studies report that dietary phosphate restriction and genetic ablation of vitamin D pathways indirectly reverse premature aging processes in these ...
Yuh Mou Sue, Yen Cheng Chen, Cheng Hsien Chen, Tso Hsiao Chen, Makoto Kuro-o, Chung Yi Cheng, Ho Han Wu   +6 more
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Role of Exercise on S-Klotho Protein Regulation: A Systematic Review

Current Aging Science, 2019
Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way of treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process.
Alejandro De-la-O, Ángel Gutiérrez, Francisco J. Amaro-Gahete, Jonatan R. Ruiz, Manuel J. Castillo, Lucas Jurado-Fasoli   +5 more
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Molecular cloning and expression of a novel klotho-related protein

Journal of Molecular Medicine, 2000
Klotho protein is a novel beta-glucosidase-like protein produced predominantly in the kidney. The klotho mouse, which genetically lacks klotho gene expression, manifests various systemic phenotypes resembling aging. In the present study we succeeded in isolating a novel human protein structurally related to klotho protein.
Masashi Mukoyama, Kiyoshi Mori, Susumu Koide, Issei Tanaka, Kazuwa Nakao, Akira Sugawara, Shoichi Ozaki, Yoshihiro Ogawa, Kensei Yahata, Yo-ichi Nabeshima, Hiroshi Arai   +10 more
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