Results 231 to 240 of about 12,957 (269)
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Alpha-Klotho protein in systemic lupus erythematosus
Clinical and Experimental Rheumatology, 2021Alpha-Klotho protein (α-Klotho) is an essential component of endocrine fibroblast growth factor receptor complexes that governs multiple metabolic processes including aging-related disorders, diabetes, cancer, arteriosclerosis, and chronic kidney disease.
Candelaria, Martín-González +6 more
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Vitamins and hormones, 2016
Klotho (KL) family proteins share one or two glycoside hydrolase (GH) motifs homologous to GH family 1. However, the biological significance of GH motifs in KL family proteins remains elusive. We describe here that KL-related protein (KLrP), which is composed of a single GH motif, is a cytosolic β-glucocerebrosidase (GCase, EC 3.2.1.145). We detected a
Y, Hayashi, M, Ito
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Klotho (KL) family proteins share one or two glycoside hydrolase (GH) motifs homologous to GH family 1. However, the biological significance of GH motifs in KL family proteins remains elusive. We describe here that KL-related protein (KLrP), which is composed of a single GH motif, is a cytosolic β-glucocerebrosidase (GCase, EC 3.2.1.145). We detected a
Y, Hayashi, M, Ito
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Klotho protein deficiency and aging
Geriatrics & Gerontology International, 2010Aging is inevitable; however, the molecular mechanism of aging has not been fully elucidated. Investigations into aging are facing difficulties because aging is influenced by complex factors such as circumstances, living habits and genetic background.
Hiroshi, Manya +2 more
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Klotho Protein Protects against Endothelial Dysfunction
Biochemical and Biophysical Research Communications, 1998Arteriosclerosis caused by aging is recognized to be a crucial risk factor of cardiovascular disease. We recently established klotho mouse which causes age-related disorders including arteriosclerosis. However, no information on endothelial function of klotho mouse or the physiological role of klotho protein as a circulating factor is available.
Y, Saito +11 more
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Regulation of Cellular Transport by Klotho Protein
Current Protein & Peptide Science, 2014The antiaging protein of Klotho is a transmembrane protein mainly expressed in the kidney, parathyroid glands and choroid plexus of the brain. The Klotho protein exists in two forms, a full-length membrane form and a soluble secreted form. The extracellular domain of Klotho can be enzymatically cleaved off and released into the systemic circulation ...
Mentor, Sopjani +4 more
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Significance of the anti-aging protein Klotho
Molecular Membrane Biology, 2013The Klotho gene was identified as an 'aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect on mineral metabolism ...
Miribane, Dërmaku-Sopjani +3 more
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Establishment of the Anti-Klotho Monoclonal Antibodies and Detection of Klotho Protein in Kidneys
Biochemical and Biophysical Research Communications, 2000A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified. The kl gene encodes a single-pass membrane protein whose extracellular domain carries homology to beta-glucosidases. There also exists a splice variant of kl mRNA which encodes a putative secreted protein in both human ...
Y, Kato +16 more
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Expression of Klotho protein in the inner ear
Hearing Research, 2002The Klotho mouse is a recently developed model that exhibits phenotypes resembling human aging. We used this model to investigate sensorineural hearing loss from the point of view that it may be considered an issue of aging. Using reverse transcription-polymerase chain reaction, Western blotting and immunohistochemical staining, we were able to confirm
Mariko, Kamemori +5 more
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Intracellular Signaling of the Aging Suppressor Protein Klotho
Current Molecular Medicine, 2015The Klotho protein deficiency is known to participate in premature aging. As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity. Due to many reasons, the insulin/insulin-like growth factor-1 (IGF-1) has been considered as a key pathway in aging research. The Klotho gene is closely related
M, Sopjani +3 more
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European Journal of Pharmacology, 2013
Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. Nonetheless, the related mechanisms were still unknown. Many studies report that dietary phosphate restriction and genetic ablation of vitamin D pathways indirectly reverse premature aging processes in these ...
Tso-Hsiao, Chen +6 more
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Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. Nonetheless, the related mechanisms were still unknown. Many studies report that dietary phosphate restriction and genetic ablation of vitamin D pathways indirectly reverse premature aging processes in these ...
Tso-Hsiao, Chen +6 more
openaire +2 more sources