Results 241 to 250 of about 12,957 (269)

α-Klotho protein in neurodegenerative and mental diseases

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019
The review aims to attract attention of psychiatrists and neurologists to a role of α-Klotho protein in biochemical mechanisms that counteract pathogenic processes of neurodegenerative and psychiatric diseases and to possible therapeutic potential of the protein.
T A, Prokhorova, I S, Boksha, O K, Savushkina, E B, Tereshkina, G Sh, Burbaeva   +4 more
openaire   +2 more sources

Role of Klotho, an antiaging protein, in pulmonary fibrosis

Archives of Toxicology, 2014
Klotho is a recently discovered antiaging protein. Although many researchers are investigating the roles of Klotho in chronic kidney diseases and cancer, however, there are no studies on the roles of Klotho in chronic pulmonary diseases. The purpose of this study was to define the role of Klotho in pulmonary fibrosis using a murine model of ovalbumin ...
In-Sik, Shin, Hyeun-Kyoo, Shin, Jong-Choon, Kim, Mee-Young, Lee   +3 more
openaire   +2 more sources

Klotho Is a Neuroprotective and Cognition-Enhancing Protein

2016
In this chapter, we will describe what has been learned about Klotho and its potential functions in the brain. Klotho is localized in the choroid plexus and, to a lesser extent, in hippocampal neurons. Cognitive decline is a common issue in human aging affecting over 50% of the population.
C R, Abraham, P C, Mullen, T, Tucker-Zhou, C D, Chen, E, Zeldich   +4 more
openaire   +2 more sources

[Klotho not only antiageing protein].

Przeglad lekarski, 2018
Klotho, the gene encoding the antiaging protein, was discovered in 1997 and named after a Greek Goddes who spun the thread of life. Numerous experiments on mice confirmed that destruction of the klotho gene or loss of klotho function leads to an accelerated aging and premature death.
Bartosz, Sosnowski, Hanna, Bachórzewska-Gajewska, Slawomir, Dobrzycki, Jolanta, Malyszko   +3 more
openaire   +1 more source

Serum Klotho protein level in patients with thyroid dysfunction

Irish Journal of Medical Science (1971 -)
This study focused on determining the new marker Klotho and its correlation with other parameters in thyroid dysfunction.Seventy-seven thyroid dysfunction patients were recruited during the period (from Aug 2024 to Dec 2024) with an age range (33-56) years. The patient group was subdivided into two groups: group I (21) Patients with Hyperthyroidism and
Noor Abd Al-Hakeem, Abdullah, Ekhlas Abdallah, Hassan   +1 more
openaire   +2 more sources

FGF23 and klotho at the intersection of kidney and cardiovascular disease

Nature Reviews Cardiology, 2023
Daniel L Edmonston, Alexander Grabner, Myles Wolf   +2 more
exaly  

Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair

Signal Transduction and Targeted Therapy, 2022
Chen Cui, Ruoshi Xu, Xi Wei
exaly  

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Nature Communications, 2022
Qian Yuan, Li Li, Yuan Tian
exaly  

Comment on: Alpha-Klotho protein in systemic lupus erythematosus

Clinical and Experimental Rheumatology, 2023
Lingzhen, Jiang, Zaixing, Yang
openaire   +2 more sources

Klotho-Protein gegen Alzheimer

DMW - Deutsche Medizinische Wochenschrift, 2015
openaire   +1 more source