Current epigenetic aspects the clinical kidney researcher should embrace [PDF]
, 2017 Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J. +5 more
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The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
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KLOTHO PROTEIN AND ATHEROSCLEROSIS
Атеросклероз, 2017 The review provides an analysis of the literature data on the Klotho protein. The discovery and in-depth study of the Klotho gene and its protein broadened the notion of natural aging. The levels of Klotho protein in serum decrease with age and with certain diseases associated with aging, in particular, such as osteoporosis, arterial hypertension ...
O. V. Timoshchenko, Yu. P. Nikitin
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Circulating markers of ageing and allostatic load: a slow train coming [PDF]
, 2017 Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully ...
Kooman, Jeroen P. +3 more
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Alkaline phosphatases in the complex chronic kidney disease-mineral and bone disorders [PDF]
, 2018 Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they
Aguilar, Armando +8 more
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From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]
, 2015 Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
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The Role of Soluble α-klotho Protein in Acromegaly
Medicina Moderna - Modern Medicine, 2023 Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects. The assumption that sαKl could inhibit the insulin-like growth factor 1 (IGF-1) signaling pathway has increased the interest of its research in acromegaly - a pathology characterized by ...
Oana PINZARIU, Carmen Emanuela GEORGESCU
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Nuclear localization of Klotho in brain: an anti-aging protein [PDF]
Neurobiology of Aging, 2012 Klotho is a putative age-suppressing gene whose overexpression in mice results in extension of life span. The Klotho gene encodes a single-pass transmembrane protein whose extracellular domain is shed and released into blood, urine, and cerebrospinal fluid, potentially functioning as a humoral factor.
Johanne Pastor +4 more
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Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study [PDF]
, 2007 BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a ...
Benjamin, Emelia J +11 more
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Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]
, 2010 Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
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