Results 21 to 30 of about 12,957 (269)
Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4. [PDF]
PLoS ONE, 2013 Klotho, a transmembrane protein, which can be cleaved off as β-glucuronidase and hormone, is released in both, kidney and choroid plexus and encountered in blood and cerebrospinal fluid.
Ahmad Almilaji +8 more
doaj +1 more source
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies [PDF]
, 2018 Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating
Burbelo +14 more
core +1 more source
The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]
, 2017 α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles +4 more
core +1 more source
Toxins, 2020 Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure.
Juan Rafael Muñoz-Castañeda +5 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To investigate the effect of FLI-1 on Klotho-mediated IGF-1R/Gi/PLC pathway on cardiomyocyte hypertrophy. Methods The cells were divided into 8 groups: control group, model group, model+NC Vector group, model+pcDNA-FLI-1 group, model+NC Vector+
TANG Gang, WANG Weiwei, ZHONG Li
doaj +1 more source
Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
, 2018 Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn +7 more
core +1 more source
Biological Role of Anti-aging Protein Klotho [PDF]
Journal of Lifestyle Medicine, 2015 Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and
Ji‐Hee Kim +4 more
openalex +4 more sources
Klotho regulates the myogenic response of muscle to mechanical loading and exercise
Experimental Physiology, 2023 Muscle growth is influenced by changes in the mechanical environment that affect the expression of genes that regulate myogenesis. We tested whether the hormone Klotho could influence the response of muscle to mechanical loading.
Eisuke Ochi +5 more
doaj +1 more source
Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]
, 2015 Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core +2 more sources