Results 41 to 50 of about 12,957 (269)

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress.

PLoS ONE, 2015
The reactive oxygen species (ROS)-sensitive apoptosis signal-regulating kinase 1 (ASK1) signaling complex is a key regulator of p38 MAPK activity, a major modulator of stress-associated with aging disorders.
Reynolds K Brobey, Mehdi Dheghani, Philip P Foster, Makoto Kuro-O, Kevin P Rosenblatt   +4 more
doaj   +1 more source

Inflammation and premature aging in advanced chronic kidney disease [PDF]

, 2017
Systemic inflammation in end-stage renal disease (ESRD) is an established risk factor for mortality and a catalyst for other complications which are related to a premature aging phenotype, including muscle wasting, vascular calcification and other forms ...
Casper G. Schalkwijk, Frank M. van der Sande, Jeroen P. Kooman, Kaysen GA, Len A. Usvyat, Marijke J. Dekker, Paul G. Shiels, Peter Kotanko, Peter Stenvinkel, Witko-Sarsat V   +9 more
core   +1 more source

Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractRestoration of blood flow to ischaemic heart inflicts ischaemia/reperfusion (I/R) injury, which manifests in metabolic and morphological disorders. Klotho is a protein with antioxidative and antiapoptotic activity, and is involved in the regulation of inflammation and fibrosis. The aim of the current research was to determine the role of Klotho
Agnieszka Olejnik, Anna Krzywonos‐Zawadzka, Marta Banaszkiewicz, Iwona Bil‐Lula   +3 more
openaire   +2 more sources

Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease [PDF]

, 2016
Background. Klotho proteins (α- and β) are membrane-based circulating proteins that regulate cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth Factors.
Agrawal, Pratik R., Assanelli, Deodato, Chen-Scarabelli, Carol, Corsetti, Giovanni, Dioguardi, Francesco S., Ferrari-Vivaldi, Mario, Flati, Vincenzo, Knight, Richard, Narula, Jagat, Pasini, Evasio, Romano, Claudia, Saravolatz, Louis, Scarabelli, Tiziano M.   +12 more
core   +2 more sources

Klotho Protein and Type 2 Diabetes Mellitus

Journal of Apitherapy and Nature, 2022
Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies. In the development of the disease, the underlying pathophysiological mechanisms are complex and multifactorial.
Eda DOKUMACIOĞLU, Hatice ISKENDER
openaire   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults [PDF]

, 2016
The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic ...
Almeida, Bruno Ratier S., Brito, Ciro J., Córdova, Cláudio, Daros, Andersen C., Ferreira, Aparecido P., Gomes, Lucy, Machado-Silva, Wilcelly, Moraes, Clayton F., Nóbrega, Otávio T., Paula, Roberta S., Souza, Vinícius C.   +10 more
core   +10 more sources

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho

Cells
Klotho is an anti-aging protein whose deletion significantly reduces lifespan in mice, while its over-expression increases lifespan. Klotho is a type-I transmembrane protein that is N-glycosylated at eight positions within its ectodomain.
Zahra Fanaei-Kahrani, Christoph Kaether
doaj   +1 more source

Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells

Research in Pharmaceutical Sciences, 2019
Klotho is considered as an anti-aging factor inducing insulin resistance and involved in type 2 diabetes. However, mechanisms by which klotho induces insulin resistance remain to be understood.
Mohamad Hasannejad, Seyed Ziaaldin Samsamshariat, Armita Esmaili, Ali Jahanian-Najafabadi   +3 more
doaj   +1 more source