Results 41 to 50 of about 11,156 (184)

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. [PDF]

, 2016
Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER).
Hrabovszky, E., Kallo, I., Liposits, Zsolt, Rodolosse, A., Sarvari, M., Solymosi, N.   +5 more
core   +1 more source

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

Cell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li, Bo Chen, Sibo Sun, Kai Wang, Yu Wang, Jianqing Wu   +5 more
wiley   +1 more source

Klotho controls the brain-immune system interface in the choroid plexus. [PDF]

, 2018
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn, Kim, Daniel, Larsson, Tobias E, Mucke, Lennart, Stein, Liana R, Yu, Gui-Qiu, Zhan, Lihong, Zhu, Lei   +7 more
core  

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Differential effects of bariatric surgery on circulating GDF15 and FGF21 levels: Implications for glycemic status and weight loss outcomes

European Journal of Clinical Investigation, EarlyView.
Our research shows different post‐surgical patters in GDF15 and FGF21 concentrations following Roux‐en‐Y gastric bypass. GDF15 levels increase significantly in patients with obesity and normoglycemia and in those with obesity and impaired glucose tolerance or type 2 diabetes, while FGF21 concentrations significantly decrease in patients with obesity ...
Laura Salmón‐Gómez, Victoria Catalán, Beatriz Ramírez, Maite Aguas‐Ayesa, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Carolina M. Perdomo, Camilo Silva, Javier Escalada, Gema Frühbeck, Javier Gómez‐Ambrosi   +12 more
wiley   +1 more source

Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model

Journal of Veterinary Medical Science, 2017
Klotho protein is recognized as having a renoprotective effect and is used as a biomarker for kidney injury. We investigated the level of Klotho protein in hyperoxaluria-induced kidney injury and the effects of vitamin E (Vit E) and vitamin C (Vit C) supplementation.
Thasinas Dissayabutra, Orapun Jaturakan, Narongsak Chaiyabutr, Anudep Rungsipipat, Anusak Kijtawornrat, Chollada Buranakarl   +5 more
openaire   +4 more sources

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects [PDF]

, 2010
Background α-Klotho (αKl) regulates mineral metabolism such as calcium ion (Ca2+) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging.
Aono, Yukiko, Econs, Michael J., Hasegawa, Hisashi, Hataya, Hiroshi, Ichikawa, Shoji, Imel, Erik A., Imura, Akihiro, Kitaoka, Taichi, Kurumatani, Norio, Murakami, Junko, Nabeshima, Yo-ichi, Nakatani, Kimihiko, Namba, Noriyuki, Okamoto, Nozomi, Ozono, Keiichi, Saito, Yoshihiko, Sakai, Tomoyuki, Shimada, Takashi, Urakawa, Itaru, Yamashita, Takeyoshi, Yamazaki, Yuji   +20 more
core   +1 more source

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

The FEBS Journal, EarlyView.
The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura, Hannah M. Nakamura, Yasumasa Iwasaki, Motomi Enomoto‐Iwamoto, Noriaki Nakashima, Satoshi Fukumoto, Maurizio Pacifici, Masahiro Iwamoto, Minoru Wakamori   +8 more
wiley   +1 more source

Klotho: An antiaging protein involved in mineral and vitamin D metabolism [PDF]

Kidney International, 2007
Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients undergoing dialysis with multiple accelerated age-related disorders, including hypoactivity, sterility, skin thinning, muscle atrophy, osteoporosis, vascular calcifications, soft-tissue calcifications, defective hearing, thymus atrophy, pulmonary emphysema ...
P. Urena Torres, Dominique Prié, Caroline Silve, Laurent Beck, Gérard Friedlander, V. Molina-Blétry   +5 more
openaire   +3 more sources

A protective role for FGF-23 in local defence against disrupted arterial wall integrity? [PDF]

, 2013
Increasing interest is focusing on the role of the FGF-23/Klotho axis in mediating vascular calcification. However, the underpinning mechanisms have yet to be fully elucidated. Murine VSMCs were cultured in calcifying medium for a 21d period. FGF-23 mRNA
Ben-Dov, Colin Farquharson, Demer, Ding, Dongxing Zhu, El-Abbadi, Eswarakumar, Franceschi, Hu, Isakova, Johnson, Jose Luis Millan, Khatiwala, Kok, Kurosu, Lim, Liu, Liu, Lorenz-Depiereux, Mackenzie, Mackenzie, Mackenzie, Mackenzie, MacRae, MacRae, MacRae, MacRae, MacRae, Medici, Murshed, Nasrallah, Neil C.W. Mackenzie, Rakugi, Razzaque, Roy, Rutsch, Rutsch, Saito, Salasznyk, Sali, Shalhoub, Shimada, Shimada, Shroff, Simmons, Sitara, Sitara, Speer, Speer, Srivaths, Urakawa, Vicky E. MacRae, Voigt, Wolf, Yamamoto, Yilmaz, Zhu, Zhu   +57 more
core   +1 more source