Results 51 to 60 of about 2,417 (172)

A parallel algorithm for generating Pareto‐optimal radiosurgery treatment plans

Medical Physics, Volume 53, Issue 5, May 2026.
Abstract Background Using inverse planning tools to create radiosurgery treatment plans is an iterative process, where clinical trade‐offs are explored by changing the relative importance given to different objectives and rerunning the optimizer until a desirable plan is found.
Joakim da Silva, Daniel Hernández Escobar, Tor Kjellsson Lindblom, Håkan Nordström, Jens Sjölund   +4 more
wiley   +1 more source

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

The Essential Role of Monte Carlo Simulations for Lung Dosimetry in Liver Radioembolization—Part B: ¹⁶⁶Ho Microspheres

Applied Sciences
This study compares dosimetric approaches for lung dosimetry in 166 radioembolization (Ho-TARE) with direct Monte Carlo (MC) simulations on a voxelized anthropomorphic phantom derived from a real patient’s CT scan, preserving the patient’s lung density ...
Edoardo d’Andrea, Andrea Politano, Bartolomeo Cassano, Nico Lanconelli, Marta Cremonesi, Vincenzo Patera, Massimiliano Pacilio   +6 more
doaj   +1 more source

Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease

Brain Pathology, Volume 36, Issue 3, May 2026.
The study analyzed the seeding activity of misfolded tau protein in Alzheimer's disease and rapidly progressive Alzheimer's disease patients and provides evidence for the existence of different tau assemblies supported by differences in cellular toxicity and morphology of thioflavin T‐positive real‐time quaking‐induced conversion products.
Matthias Schmitz, Katrin Thüne, Anna‐Lisa Fischer, Peter Hermann, Maria Cramm, Leonie Sheila Kadel, Wiebke Möbius, Jakob Matschke, Tayyaba Saleem, Neelam Younas, Saima Zafar, Hermann Altmeppen, Markus Glatzel, Inga Zerr   +13 more
wiley   +1 more source

Assessing the Progress of Stock Rebuilding in the Northeast Atlantic Against Levels That Can Produce Maximum Sustainable Yield

Fish and Fisheries, Volume 27, Issue 3, Page 519-536, May 2026.
ABSTRACT Rebuilding fish stocks to levels above which they produce Maximum Sustainable Yield (MSY) is a management aim for all European commercially exploited stocks. Progress is typically monitored against the fishing mortality that produces MSY in the long term (FMSY), however, the corresponding biomass target (BMSY) is rarely evaluated nor reported.
Henning Winker, Massimiliano Cardinale, Rishi Sharma, Laurence T. Kell, Iago Mosqueira, Christopher Griffiths   +5 more
wiley   +1 more source

On the K‐stability of blow‐ups of projective bundles

Journal of the London Mathematical Society, Volume 113, Issue 5, May 2026.
Abstract We investigate the K‐stability of certain blow‐ups of P1$\mathbb {P}^1$‐bundles over a Fano variety V$V$, where the P1$\mathbb {P}^1$‐bundle is the projective compactification of a line bundle L$L$ proportional to −KV$-K_V$ and the center of the blow‐up is the image along a positive section of a divisor B$B$ also proportional to L$L$. When V$V$
Daniel Mallory
wiley   +1 more source

Aneurysm Wall Enhancement and Probability of Instability in Unruptured Intracranial Aneurysms: A Long‐Term Follow‐Up Study

Annals of Neurology, Volume 99, Issue 4, Page 863-870, April 2026.
Objective Aneurysm wall enhancement (AWE) may predict aneurysm growth and rupture in the short‐term, but there is a lack of long‐term follow‐up studies. We aimed to determine whether unruptured intracranial aneurysms (UIAs) with AWE have a higher probability of aneurysm instability during long‐term follow‐up compared with those without AWE. Methods For
Laura T. van der Kamp, Maarten J. Kamphuis, Olivier Naggara, Thomas Le Tat, Gabriel J. E. Rinkel, Gérard A. P. de Kort, Ruben P. A. van Eijk, Jeroen Hendrikse, Irene C. van der Schaaf, Mervyn D. I. Vergouwen   +9 more
wiley   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, Volume 99, Issue 4, Page 897-911, April 2026.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

SKRINING FITOKIMIA DAN ANALISIS KROMATOGRAFI LAPIS TIPIS EKSTRAK TANAMAN PATIKAN KEBO (Euphorbia hirta L.)

Jurnal Ilmiah Medicamento, 2017
Tanaman obat mengandung berbagai macam kandungan fitokimia yang berperan dalam pengembangan obat. Herba Patikan Kebo (Euphorbia hirta L.) adalah salah satu tanaman obat yang tergolong dalam Famili Euphorbiaceae.
Putu Era Sandhi Kusuma Yuda, Erna Cahyaningsih, Ni Putu Yuni Winariyanthi   +2 more
doaj   +5 more sources

On the Use of Evolutionary Algorithms to Improve the Robustness of Continuous Speech Recognition Systems in Adverse Conditions

EURASIP Journal on Advances in Signal Processing, 2003
Limiting the decrease in performance due to acoustic environment changes remains a major challenge for continuous speech recognition (CSR) systems. We propose a novel approach which combines the Karhunen-Loève transform (KLT) in the mel-frequency ...
Sid-Ahmed Selouani, Douglas O'Shaughnessy   +1 more
doaj   +1 more source